Fetal lymphocyte subpopulations in red blood cell iso-immunised pregnancies
| dc.contributor.author | Thilaganathan, B. | en |
| dc.contributor.author | Makrydimas, G. | en |
| dc.contributor.author | Plachouras, N. | en |
| dc.contributor.author | Nicolaides, K. H. | en |
| dc.date.accessioned | 2015-11-24T19:15:55Z | |
| dc.date.available | 2015-11-24T19:15:55Z | |
| dc.identifier.issn | 0306-5456 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/21584 | |
| dc.rights | Default Licence | - |
| dc.subject | Anemia/blood | en |
| dc.subject | B-Lymphocyte Subsets | en |
| dc.subject | Cross-Sectional Studies | en |
| dc.subject | Female | en |
| dc.subject | Fetal Diseases/blood | en |
| dc.subject | Fetal Hemoglobin/analysis | en |
| dc.subject | Gestational Age | en |
| dc.subject | Humans | en |
| dc.subject | Leukocyte Count | en |
| dc.subject | Pregnancy | en |
| dc.subject | Rh Isoimmunization/*blood | en |
| dc.subject | *T-Lymphocyte Subsets | en |
| dc.subject | T-Lymphocytes, Helper-Inducer | en |
| dc.title | Fetal lymphocyte subpopulations in red blood cell iso-immunised pregnancies | en |
| heal.abstract | OBJECTIVE: To study the association between fetal anaemia and alterations in lymphocyte subpopulations. DESIGN: Cross-sectional study. SETTING: The Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London. SUBJECTS: Forty-three red blood cell iso-immunised pregnancies undergoing cordocentesis at 19 to 38 weeks gestation. MAIN OUTCOME MEASURES: Fetal blood haemoglobin concentration, erythroblast count and lymphocyte subpopulations. RESULTS: The mean T (CD3+), B (CD19+), T-helper (CD4+), T-suppressor/cytotoxic (CD8+) and natural killer (NK: CD16+/CD56+) cell counts in the anaemic fetuses were significantly lower than the appropriate normal mean for gestation (CD3+: t = -3.25, P < 0.01; CD19+: t = -2.14, P < 0.05; CD4+: t -4.03, P < 0.001; CD8+: t = -3.39, P < 0.01 and CD16+/CD56+: t = -3.49, P < 0.01). Furthermore, there was a significant association between the decrease in T lymphocyte number and the degree of fetal anaemia (r = 0.342, P < 0.05). CONCLUSIONS: Fetuses from red blood cell iso-immunised pregnancies exhibit nonselective lymphopenia that is proportional to the degree of anaemia. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/7515274 | - |
| heal.journalName | Br J Obstet Gynaecol | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1994 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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