Synthesis of observational studies should consider credibility ceilings
| dc.contributor.author | Salanti, G. | en |
| dc.contributor.author | Ioannidis, J. P. | en |
| dc.date.accessioned | 2015-11-24T19:43:26Z | |
| dc.date.available | 2015-11-24T19:43:26Z | |
| dc.identifier.issn | 1878-5921 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/24757 | |
| dc.rights | Default Licence | - |
| dc.subject | Algorithms | en |
| dc.subject | *Bias (Epidemiology) | en |
| dc.subject | *Data Interpretation, Statistical | en |
| dc.subject | Fatty Acids, Omega-3/administration & dosage | en |
| dc.subject | Hair Dyes/adverse effects | en |
| dc.subject | Hospital Mortality | en |
| dc.subject | Hospitals, Teaching/statistics & numerical data | en |
| dc.subject | Humans | en |
| dc.subject | Likelihood Functions | en |
| dc.subject | Lymphoma, Non-Hodgkin/epidemiology | en |
| dc.subject | *Meta-Analysis as Topic | en |
| dc.subject | Research Design/standards | en |
| dc.subject | Risk | en |
| dc.title | Synthesis of observational studies should consider credibility ceilings | en |
| heal.abstract | OBJECTIVE: Meta-analyses of observational studies often get spuriously precise results. We aimed to factor this skepticism in meta-analysis calculations. STUDY DESIGN AND SETTING: We developed a simple sensitivity analysis starting from the assumption that any single observational study cannot give us more than a maximum certainty c% (called credibility ceiling) that an effect is in a particular direction and not in the other. Each study included in meta-analysis is adjusted for different credibility ceilings c and the consistency of the conclusion examined. We applied the method in three meta-analyses of observational studies with nominally statistically significant summary effects (mortality with teaching versus nonteaching health care; risk of non-Hodgkin's lymphoma with hair dyes; mortality with omega-3 fatty acids). RESULTS: Between-study heterogeneity I(2) estimates dropped from 36%-72% without a ceiling effect to 0% with ceilings of 9%, 4%, and 4% in the three meta-analyses, respectively. Nominal statistical significance was lost with ceilings of 10%, 8%, and 11%, respectively. The likelihood ratios suggested that even with minimal ceiling effects, there was no strong support for the credibility of each of these three associations. CONCLUSIONS: Consideration of credibility ceilings allows conservative interpretation of observational evidence and can be applied routinely to meta-analyses of observational studies. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1016/j.jclinepi.2008.05.014 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/19131013 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S089543560800259X/1-s2.0-S089543560800259X-main.pdf?_tid=6bb8950a584764dd6c01254f0b98148c&acdnat=1333018214_bed2bc124839b2a6f5e3288c1f830570 | - |
| heal.journalName | J Clin Epidemiol | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2009 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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