Acute infection with Epstein-Barr virus is associated with atherogenic lipid changes
Φόρτωση...
Ημερομηνία
Συγγραφείς
Apostolou, F.
Gazi, I. F.
Lagos, K.
Tellis, C. C.
Tselepis, A. D.
Liberopoulos, E. N.
Elisaf, M.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Atherosclerosis
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Objective: To evaluate the effects of acute infection with Epstein-Barr virus (infectious mononucleosis, IM) on lipids and lipoproteins. Methods: Fasting serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TGs), apolipoproteins (apo) A-I, B, E, C-II, C-III and lipoprotein (a) [Lp(a)] were determined in patients with IM on diagnosis and 4 months after the resolution of febrile illness and in age-and sex-matched controls. Activities of cholesteryl-ester transfer protein (CETP), lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) and paraoxonase 1 (PON1) as well as levels of several cytokines were determined. LDL subclass analysis was performed with the Lipoprint LDL System. Results: Twenty-nine patients (16 males, aged 24.3 perpendicular to 14.6 years) and 30 controls were included. TC, HDL-C, LDL-C, apoA-I, apoB, apoC-III and Lp(a) levels were lower at baseline whereas apoB/apoA-I ratio, TG levels and CETP activity were elevated compared with 4 months later. At baseline, higher levels in cytokines and the cholesterol concentration of small-dense LDL particles (sdLDL-C) were noticed, whereas LDL particle size was lower compared with follow-up. Activities of Lp-PLA(2) and PON1 were similar at baseline and 4 months later. Four months after the resolution of IM levels of TGs, apoE, apoC-III, Lp(a), sdLDL-C and cytokines as well as LDL particle size, apoB/apoA-I ratio, CETP and Lp-PLA(2) activities were similar to controls. PON1 activities both at baseline and 4 months later were lower in patients compared with controls. Conclusions: IMis associated with atherogenic changes of lipids and lipoproteins that are partially restored 4 months after its resolution. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
Περιγραφή
Λέξεις-κλειδιά
epstein-barr virus, lipids, small-dense ldl particles, cytokines, lipoprotein-associated phospholipase a(2) (lp-pla(2)), activating-factor acetylhydrolase, acute-phase response, acquired-immunodeficiency-syndrome, serum paraoxonase-1 activity, high-density-lipoprotein, messenger-rna levels, phospholipase a(2), ldl particles, human plasma, atherosclerosis
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000282678500043
http://ac.els-cdn.com/S0021915010004247/1-s2.0-S0021915010004247-main.pdf?_tid=61e633bf00552b2a704f3fe12bfaff4d&acdnat=1333110925_e660b7a56b951febfe10782f5938d5f6
http://ac.els-cdn.com/S0021915010004247/1-s2.0-S0021915010004247-main.pdf?_tid=61e633bf00552b2a704f3fe12bfaff4d&acdnat=1333110925_e660b7a56b951febfe10782f5938d5f6
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας