Effects of different chemotherapy regimens on survival for advanced cervical cancer: systematic review and meta-analysis
| dc.contributor.author | Tzioras, S. | en |
| dc.contributor.author | Pavlidis, N. | en |
| dc.contributor.author | Paraskevaidis, E. | en |
| dc.contributor.author | Ioannidis, J. P. | en |
| dc.date.accessioned | 2015-11-24T19:21:22Z | |
| dc.date.available | 2015-11-24T19:21:22Z | |
| dc.identifier.issn | 0305-7372 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22097 | |
| dc.rights | Default Licence | - |
| dc.subject | Antineoplastic Agents/administration & dosage/*therapeutic use | en |
| dc.subject | Antineoplastic Combined Chemotherapy Protocols | en |
| dc.subject | Cisplatin/administration & dosage/therapeutic use | en |
| dc.subject | Combined Modality Therapy | en |
| dc.subject | Female | en |
| dc.subject | Humans | en |
| dc.subject | Platinum Compounds/administration & dosage/therapeutic use | en |
| dc.subject | Randomized Controlled Trials as Topic | en |
| dc.subject | Survival Analysis | en |
| dc.subject | Uterine Cervical Neoplasms/*drug therapy/radiotherapy | en |
| dc.title | Effects of different chemotherapy regimens on survival for advanced cervical cancer: systematic review and meta-analysis | en |
| heal.abstract | BACKGROUND: A large number of trials have assessed various chemotherapy regimens for the treatment of advanced cervical cancer, but there is uncertainty about the magnitude of survival benefits. METHODS: We searched (last update January 2006) for trials in women with locally advanced or disseminated cervical cancer that compared neo-adjuvant or concurrent chemotherapy plus radiotherapy versus radiotherapy alone; or different chemotherapy regimens among themselves (with or without background radiotherapy in both arms). Sixty-five trials were identified with survival data on 11,180 women. Results for survival were combined with fixed and random effects models and between-study heterogeneity was estimated. Separate results were obtained for different regimens, cycle length, and type of chemotherapy (neo-adjuvant, concurrent, without radiotherapy). RESULTS: Twenty two comparisons had survival data on 3837 women randomized to receive chemotherapy plus radiotherapy versus radiotherapy alone; the summary relative hazard for mortality was 0.95, 95% CI, 0.83-1.08. Modest between-study heterogeneity (I2=38%) seemed to be due to contradictory results in early trials; trials published in the last decade had a summary relative hazard 0.89 (95% CI, 0.78-1.02) and no between-study heterogeneity (I2=0%). Results were similar for neo-adjuvant chemotherapy and for concurrent chemo-radiotherapy. Cisplatin or cisplatin-based combinations had no significant benefit overall, but a potential benefit was seen with short-length cycles (14 days) and a marginally significant harm with longer-length cycles (summary relative hazards 0.80, 95% CI, 0.66-0.99 and 1.18, 95% CI, 1.02-1.38, respectively). The summary relative hazard was 1.02, (95% CI, 0.84-1.24) for trials using neo-adjuvant chemotherapy and 0.85 (95% CI, 0.73-1.00) for trials using concurrent chemotherapy. CONCLUSIONS: Evidence on chemotherapy in women with advanced cervical cancer is not encouraging for major survival benefits. However, small benefits have been observed in some trials, especially with short-length cycles of cisplatin-based regimens and concurrent chemotherapy and radiotherapy. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1016/j.ctrv.2006.09.007 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/17112673 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0305737206001861/1-s2.0-S0305737206001861-main.pdf?_tid=7f1202e55469142b8b9007b65a23522e&acdnat=1333714106_9a26cd51320e2128365fa819fced5f52 | - |
| heal.journalName | Cancer Treat Rev | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2007 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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