Should we advise patients undergoing IVF to start a cycle leading to a day 3 or a day 5 transfer?
| dc.contributor.author | Kolibianakis, E. M. | en |
| dc.contributor.author | Zikopoulos, K. | en |
| dc.contributor.author | Verpoest, W. | en |
| dc.contributor.author | Camus, M. | en |
| dc.contributor.author | Joris, H. | en |
| dc.contributor.author | Van Steirteghem, A. C. | en |
| dc.contributor.author | Devroey, P. | en |
| dc.date.accessioned | 2015-11-24T18:51:41Z | |
| dc.date.available | 2015-11-24T18:51:41Z | |
| dc.identifier.issn | 0268-1161 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/18292 | |
| dc.rights | Default Licence | - |
| dc.subject | Adult | en |
| dc.subject | Blastocyst/cytology/physiology | en |
| dc.subject | Cryopreservation | en |
| dc.subject | Embryo Culture Techniques | en |
| dc.subject | Embryo Transfer | en |
| dc.subject | Female | en |
| dc.subject | Fertilization in Vitro/*methods | en |
| dc.subject | Follicle Stimulating Hormone/therapeutic use | en |
| dc.subject | Gonadotropin-Releasing Hormone/agonists/antagonists & inhibitors | en |
| dc.subject | Humans | en |
| dc.subject | Infertility, Female/etiology/therapy | en |
| dc.subject | Ovulation Induction/*methods | en |
| dc.subject | Pregnancy | en |
| dc.subject | Pregnancy Rate | en |
| dc.subject | Time Factors | en |
| dc.title | Should we advise patients undergoing IVF to start a cycle leading to a day 3 or a day 5 transfer? | en |
| heal.abstract | BACKGROUND: The aim of this study was to compare ongoing pregnancy rates per started cycle between patients randomized at consultation to have embryo transfer either on day 3 or on day 5 of in-vitro culture. METHODS: All patients <43 years of age for whom IVF was indicated were allowed to participate in the study (day 3 group, 234 patients; day 5 group, 226 patients). Ovarian stimulation was performed either using GnRH antagonists/recombinant FSH (rFSH) (day 3, 70.1% of patients; day 5, 72.6% of patients) or using the long GnRH agonist protocol/urinary gonadotropins (day 3, 29.9% of patients; day 5 27.4% of patients). RESULTS: The random decision to initiate a cycle leading to day 5 as compared with a day 3 transfer was associated with a significantly lower chance of embryo cryopreservation (day 3, 61.5%; day 5, 50.4%; P<0.02). Ongoing pregnancy rate per started cycle did not differ between the two groups compared [day 3, 32.1%, 95% confidence interval (CI) 26.4-38.2%; day 5, 33.2%, 95% CI 27.3-39.5%]. CONCLUSIONS: Advising patients at consultation to initiate an IVF cycle leading to a day 5 as compared with a day 3 transfer does not appear to increase the probability of ongoing pregnancy, and is associated with a significantly lower probability of obtaining cryopreserved embryos. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1093/humrep/deh447 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/15298978 | - |
| heal.identifier.secondary | http://humrep.oxfordjournals.org/content/19/11/2550.full.pdf | - |
| heal.journalName | Hum Reprod | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2004 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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