p16(INK4a) immunostaining in cytological and histological specimens from the uterine cervix: a systematic review and meta-analysis
Φόρτωση...
Ημερομηνία
Συγγραφείς
Tsoumpou, I.
Arbyn, M.
Kyrgiou, M.
Wentzensen, N.
Koliopoulos, G.
Martin-Hirsch, P.
Malamou-Mitsi, V.
Paraskevaidis, E.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Cancer Treat Rev
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
BACKGROUND: P16(INK4a) is a biomarker for transforming HPV infections that could act as an adjunct to current cytological and histological assessment of cervical smears and biopsies, allowing the identification of those women with ambiguous results that require referral to colposcopy and potentially treatment. MATERIAL AND METHODS: We conducted a systematic review of all studies that evaluated the use of p16(INK4a) in cytological or histological specimens from the uterine cervix. We also estimated the mean proportion of samples that were positive for p16(INK4a) in cytology and histology, stratified by the grade of the lesion. RESULTS: Sixty-one studies were included. The proportion of cervical smears overexpressing p16(INK4a) increased with the severity of cytological abnormality. Among normal smears, only 12% (95% CI: 7-17%) were positive for the biomarker compared to 45% of ASCUS and LSIL (95% CI: 35-54% and 37-57%, respectively) and 89% of HSIL smears (95% CI: 84-95%). Similarly, in histology only 2% of normal biopsies (95% CI: 0.4-30%) and 38% of CIN1 (95% CI: 23-53%) showed diffuse staining for p16(INK4a) compared to 68% of CIN2 (95% CI: 44-92%) and 82% of CIN3 (95% CI: 72-92%). CONCLUSION: Although there is good evidence that p16(INK4a) immunostaining correlates with the severity of cytological/histological abnormalities, the reproducibility is limited due to insufficiently standardized interpretation of the immunostaining. Therefore, a consensus needs to be reached regarding the evaluation of p16(INK4a) staining and the biomarker needs to be assessed in various clinical settings addressing specific clinical questions.
Περιγραφή
Λέξεις-κλειδιά
*Alphapapillomavirus, Biological Markers/analysis, Biopsy, Cervical Intraepithelial Neoplasia/chemistry/diagnosis, Cervix Uteri/*chemistry/pathology/virology, Colposcopy, Cyclin-Dependent Kinase Inhibitor p16/*analysis, Cytological Techniques/utilization, Female, Histological Techniques/utilization, Humans, Immunohistochemistry/utilization, Neoplasm Proteins/analysis, Papillomavirus Infections/*diagnosis/metabolism, Predictive Value of Tests, Prospective Studies, Research Design, Retrospective Studies, Tumor Markers, Biological/analysis, Uterine Cervical Dysplasia/metabolism/virology, Uterine Cervical Neoplasms/*chemistry/diagnosis/virology, Uterine Cervicitis/*diagnosis/metabolism, Vaginal Smears
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/19261387
http://ac.els-cdn.com/S0305737208002958/1-s2.0-S0305737208002958-main.pdf?_tid=927e3f7531ab275f0e1fcac1c5354ea1&acdnat=1333714015_88398090b595f729a78c78ef55337b18
http://ac.els-cdn.com/S0305737208002958/1-s2.0-S0305737208002958-main.pdf?_tid=927e3f7531ab275f0e1fcac1c5354ea1&acdnat=1333714015_88398090b595f729a78c78ef55337b18
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής