Tracheal gas insufflation augments CO2 clearance during mechanical ventilation

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dc.contributor.authorRavenscraft, S. A.en
dc.contributor.authorBurke, W. C.en
dc.contributor.authorNahum, A.en
dc.contributor.authorAdams, A. B.en
dc.contributor.authorNakos, G.en
dc.contributor.authorMarcy, T. W.en
dc.contributor.authorMarini, J. J.en
dc.date.accessioned2015-11-24T19:12:23Z
dc.date.available2015-11-24T19:12:23Z
dc.identifier.issn0003-0805-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21065
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectCarbon Dioxide/analysis/*metabolismen
dc.subjectEfficiencyen
dc.subjectFemaleen
dc.subjectFunctional Residual Capacity/physiologyen
dc.subjectHumansen
dc.subjectInsufflationen
dc.subjectIntubation, Intratracheal/instrumentation/*methodsen
dc.subjectLung/physiopathologyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectMonitoring, Physiologic/methodsen
dc.subjectOxygen/*administration & dosageen
dc.subject*Positive-Pressure Respirationen
dc.subjectPressureen
dc.subjectPulmonary Gas Exchange/physiologyen
dc.subjectPulmonary Ventilation/physiologyen
dc.subjectRespiration/physiologyen
dc.subjectRespiratory Dead Space/physiologyen
dc.subjectRespiratory Insufficiency/*therapyen
dc.subjectTidal Volume/physiologyen
dc.titleTracheal gas insufflation augments CO2 clearance during mechanical ventilationen
heal.abstractA technique that improves the efficiency of alveolar ventilation should decrease the pressure required and reduce the potential for lung injury during mechanical ventilation. Alveolar ventilation may be improved by replacing a portion of the anatomic dead space with fresh gas via an intratracheal catheter. We studied the effect of intratracheal gas insufflation as an adjunct to volume cycled ventilation in eight sedated, paralyzed patients with a variety of lung disorders. Continuous flows of 2, 4, and 6 L/min were delivered through a catheter positioned 1 or 10 cm above the carina. Carbon dioxide production, inspiratory minute ventilation, and peak and mean airway pressures did not change over the range of flows tested. PaCO2 and dead space volume/tidal volume decreased significantly as joint functions of catheter flow and position (p < 0.001). The highest catheter flow (6 L/min) and most distal catheter position (1 cm above the carina) were the most effective combination tested, averaging a 15% reduction in PaCO2 (range 9 to 23%). Certain characteristics of the expiratory capnogram were helpful in predicting the observed reduction in PaCO2. Tracheal gas insufflation may eventually prove a useful adjunct to a pressure-targeted strategy of ventilatory management (in either volume-cycled or pressure controlled modes), particularly when the total dead space is heavily influenced by its anatomic component.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/8342897-
heal.journalNameAm Rev Respir Disen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1993-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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