Coexpression of neuronal, glial, and major histocompatibility complex class II antigens on retinoblastoma cells

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dc.contributor.authorDetrick, B.en
dc.contributor.authorChader, G. J.en
dc.contributor.authorRodrigues, M.en
dc.contributor.authorKyritsis, A. P.en
dc.contributor.authorChan, C. C.en
dc.contributor.authorHooks, J. J.en
dc.date.accessioned2015-11-24T19:30:03Z
dc.date.available2015-11-24T19:30:03Z
dc.identifier.issn0008-5472-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23013
dc.rightsDefault Licence-
dc.subjectAntigens/analysisen
dc.subjectArrestinen
dc.subjectChild, Preschoolen
dc.subjectEye Neoplasms/*immunologyen
dc.subjectEye Proteins/analysisen
dc.subjectFluorescent Antibody Techniqueen
dc.subjectGlial Fibrillary Acidic Protein/analysisen
dc.subjectHLA-D Antigens/*analysisen
dc.subjectHLA-DQ Antigens/*analysisen
dc.subjectHLA-DR Antigens/*analysisen
dc.subjectHumansen
dc.subjectInterferon-gamma/pharmacologyen
dc.subjectMaleen
dc.subjectNeuroglia/*immunologyen
dc.subjectNeurons/*immunologyen
dc.subjectRetina/immunologyen
dc.subjectRetinoblastoma/*immunologyen
dc.subjectTumor Cells, Cultureden
dc.titleCoexpression of neuronal, glial, and major histocompatibility complex class II antigens on retinoblastoma cellsen
heal.abstractThis study identifies the presence of major histocompatibility complex class II antigens on retinoblastoma cells. In addition, the modulation of HLA-DR by interferon-gamma as well as the preferential expression of this major histocompatibility complex molecule over HLA-DQ is described. Double labeling experiments revealed that HLA-DR antigen is shared concomitantly with cells of glial and neuronal character. Investigations such as these underscore the possibility that expression of major histocompatibility complex class II antigens may function as immunological components in the host or play a role in the cellular differentiation of these tumor cells.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/3125966-
heal.journalNameCancer Resen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1988-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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