Action of a novel pyrrolo[1,2-c][1.3]benzodiazepine on the viability of Jurkat and neuronal/glial cells

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dc.contributor.authorRotas, G.en
dc.contributor.authorNatchkebia, K.en
dc.contributor.authorNatsvlishvili, N.en
dc.contributor.authorKekelidze, M.en
dc.contributor.authorKimbaris, A.en
dc.contributor.authorVarvounis, G.en
dc.contributor.authorMikeladze, D.en
dc.date.accessioned2015-11-24T16:42:52Z
dc.date.available2015-11-24T16:42:52Z
dc.identifier.issn0960-894X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/8610
dc.rightsDefault Licence-
dc.subjectpyrrolobenzodiazepineen
dc.subjectneuronal/glial cellsen
dc.subjecttransformeden
dc.subjectjurkat cellsen
dc.subjectDNA cleavageen
dc.subjectanticancer drugsen
dc.subjectDNA-bindingen
dc.subjectanthramycinen
dc.subjectdamageen
dc.subjectapoptosisen
dc.subjectadductsen
dc.titleAction of a novel pyrrolo[1,2-c][1.3]benzodiazepine on the viability of Jurkat and neuronal/glial cellsen
heal.abstractWe have designed and synthesized several structural isomers of anthramycin (heterocycles 2, 3, 5, 6, and 8) and found that, in particular, pyrrolobenzodiazepine 8 induces DNA cleavage and formation of small fragments of DNA. The cytotoxic effects of 8 were manifested with both non-transformed primary neuronal/glial cells and transformed Jurkat cells. The other compounds did not change the viability either of transformed or of non-transformed cells, and induced DNA cleavage to a lesser extent. (c) 2005 Elsevier Ltd. All rights reserved.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1016/j.bmcl.2005.05.006-
heal.identifier.secondary<Go to ISI>://000230062300009-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0960894X05005652/1-s2.0-S0960894X05005652-main.pdf?_tid=dabb64b2-34ac-11e3-8bbd-00000aab0f26&acdnat=1381740456_449d658683f80f144b0232a8c2290084-
heal.journalNameBioorganic and Medicinal Chemistry Lettersen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2005-
heal.publisherElsevieren
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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