Compliance with lipid-lowering therapy and its impact on cardiovascular morbidity and mortality
Φόρτωση...
Ημερομηνία
Συγγραφείς
Liberopoulos, E. N.
Florentin, M.
Mikhailidis, D. P.
Elisaf, M. S.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Expert Opin Drug Saf
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
BACKGROUND: Hypercholesterolemia is a major risk factor for cardiovascular disease. OBJECTIVE: Treatment with hypolipidemic agents reduces the risk of vascular events both in primary and secondary prevention. Although compliance with lipid-lowering therapy is an important determinant of cardiovascular clinical outcomes, relatively little attention is being paid to this issue by physicians. METHODS: We searched the literature using Pubmed up to 5 August 2008. RESULTS: Compliance with lipid-lowering therapy is poor in clinical practice, especially in primary prevention. As many as 6 out of 10 patients may stop taking statins during the first 6 months following initiation of treatment. Poor compliance has been associated with worse clinical outcome and increased cardiovascular morbidity and mortality. Importantly, statin withdrawal may be even worse compared with not taking statins at all. Several strategies may increase treatment adherence. CONCLUSIONS: Poor compliance with lipid-lowering treatment is an important health issue that has been associated with unfavorable cardiovascular outcome. Increasing adherence rates should become a major concern for physicians.
Περιγραφή
Λέξεις-κλειδιά
Cardiovascular Diseases/etiology/mortality/*prevention & control, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors/*administration & dosage, Hypercholesterolemia/complications, Hypolipidemic Agents/*administration & dosage, *Medication Adherence/statistics & numerical data, Randomized Controlled Trials as Topic, Risk Factors, Treatment Outcome
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/18983218
http://informahealthcare.com/doi/abs/10.1517/14740330802396984
http://informahealthcare.com/doi/abs/10.1517/14740330802396984
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής