Prediction of long-term functional outcome in patients with acute ischemic non-embolic stroke
Φόρτωση...
Ημερομηνία
Συγγραφείς
Protopsaltis, J.
Kokkoris, S.
Korantzopoulos, P.
Milionis, H. J.
Karzi, E.
Anastasopoulou, A.
Filioti, K.
Antonopoulos, S.
Melidonis, A.
Giannoulis, G.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Atherosclerosis
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
In a prospective observational study, we assessed the relative value of conventional stroke risk factors and emerging markers in the prediction of functional outcome of patients surviving the acute phase of an ischemic non-embolic stroke. All available eligible patients consecutively admitted due to a first-ever acute ischemic non-embolic stroke during a 2-year period were evaluated. In a total of 105 patients (54 males, 51 diabetic) a series of clinical, biochemical and imaging characteristics were recorded, including demographic data, blood pressure, serum glucose, insulin, lipids, inflammatory markers, intima-media thickness of the carotid arteries (IMT), brain damage location and size of the infarct volume. Barthel Activities of Daily Living Index (BI) scale was used to assess the severity of neurological deficit on admission and the functional outcome 6 months after discharge. Brain infarct volume, stroke location in the anterior circulation, age, diabetes mellitus, IMT and plasma interleukin-1beta levels proved to be significant determinants of long-term functional outcome, assessed by BI disability score. ROC curve analyses indicated that the infarct volume is superior to other predictors in the diagnosis of patients with unfavorable functional outcome (BI<95) at 6 months post-discharge (area under the curve, AUC=0.80, 95% confidence interval 0.64-0.95; p=0.003). Significant differences in the mean infarct volume were noted among age tertiles, with the diabetic patients in the 3rd tertile of age experiencing the worst outcome (LSD test, p=0.019). Taken together, the assessment of infarct volume seems to have a significant predictive value regarding long-term functional outcome, especially in the elderly diabetic patients.
Περιγραφή
Λέξεις-κλειδιά
Activities of Daily Living, Aged, Aged, 80 and over, Area Under Curve, Brain Ischemia/diagnosis/physiopathology/therapy, Diabetes Complications, Female, Humans, Ischemia, Male, Prospective Studies, Reproducibility of Results, Stroke/*diagnosis/physiopathology/*therapy, Tomography, X-Ray Computed/methods, Treatment Outcome
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/18602106
http://ac.els-cdn.com/S0021915008003821/1-s2.0-S0021915008003821-main.pdf?_tid=7ffd0d42431dfc667739bdf5ba3ad413&acdnat=1333965349_a9f9b541857df0aa0395d99d0f496bf0
http://ac.els-cdn.com/S0021915008003821/1-s2.0-S0021915008003821-main.pdf?_tid=7ffd0d42431dfc667739bdf5ba3ad413&acdnat=1333965349_a9f9b541857df0aa0395d99d0f496bf0
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής