Biocatalytic preparation of acylated derivatives of flavonoid glycosides enhances their antioxidant and antimicrobial activity
Φόρτωση...
Ημερομηνία
Συγγραφείς
Mellou, F.
Lazari, D.
Skaltsa, H.
Tselepis, A. D.
Kolisis, E.
Stamatis, H.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Journal of Biotechnology
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Enzymatic synthesis of acylated derivatives of a monosaccharidic flavonoid chrysoeriol-7-O-beta-D-(3"-E-p-coumaroyl)glucopyranoside as well as of a disaccharidic flavonoid chrysoeriol-7-[6'"-O-acetyl-beta-D-allosyl-(1 --> 2)-beta-D-glucopyranoside], isolated from Greek endemic plants, was performed using an immobilized Candida antarctica lipase in non-toxic organic solvents. The influence of the reaction parameters such as the molar ratio of acyl donor to flavonoid, as well as the nature of the acyl donor, on the performance of the biocatalytic process was pointed out using the acylation of naringin as a model reaction. With vinyl laurate as acyl donor, the highest conversion was observed at relatively high molar ratio (greater than or equal to 10), using acetone as solvent. Lipase exhibits specificity towards primary alcohol of the glucose moiety of both flavonoid glycosides. The introduction of an acyl group into glucosylated flavonoids significantly improved their antioxidant activity towards both LDL and serum model in vitro. Furthermore, the acylated derivative of disaccharidic flavonoid increased its antimicrobial activity against two Gram-positive bacteria. (C) 2004 Elsevier B.V. All rights reserved.
Περιγραφή
Λέξεις-κλειδιά
lipase, esterification, flavonoids, biocatalysis, ldl oxidation, antioxidants, low-density-lipoprotein, enzymatic-synthesis, phenolic-acids, ldl oxidation, organic media, water-content, lipase, inhibition, esters, esterification
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000227313600010
http://ac.els-cdn.com/S0168165604006091/1-s2.0-S0168165604006091-main.pdf?_tid=d90b44cce35c203ab4f4785032127fc3&acdnat=1335510755_4766de0e80faa0eb30ba304c85aa582a
http://ac.els-cdn.com/S0168165604006091/1-s2.0-S0168165604006091-main.pdf?_tid=d90b44cce35c203ab4f4785032127fc3&acdnat=1335510755_4766de0e80faa0eb30ba304c85aa582a
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιών