Expression of cell adhesion molecule CD44 in human gastric cancer. A correlation with P53 and Rb proteins, the HLA-DR antigen and the proliferative activity

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dc.contributor.authorGoussia, A. C.en
dc.contributor.authorIoachim, E. E.en
dc.contributor.authorAgnantis, N. J.en
dc.contributor.authorZagorianakou, P.en
dc.contributor.authorVougiouklakis, T.en
dc.contributor.authorTsianos, E. V.en
dc.contributor.authorKappas, A.en
dc.date.accessioned2015-11-24T19:16:43Z
dc.date.available2015-11-24T19:16:43Z
dc.identifier.issn0886-3849-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21704
dc.rightsDefault Licence-
dc.subjectdiffuse-typeen
dc.subjectdifferential expressionen
dc.subjectextracellular-matrixen
dc.subjectvarianten
dc.subjectisoformsen
dc.subjectintestinal-typeen
dc.subjectadenocarcinomasen
dc.subjectprogressionen
dc.subjectmetastasisen
dc.subjectintegrinsen
dc.subjectcarcinomaen
dc.titleExpression of cell adhesion molecule CD44 in human gastric cancer. A correlation with P53 and Rb proteins, the HLA-DR antigen and the proliferative activityen
heal.abstractThe expression of the CD44 standard (CD44s) was examined immunohistochemically in a series of 61 gastric adenocarcinomas and analyzed the relation with the expression of HLA-DR antigen, the p53 and Rb protein expression, the proliferation indices Ki-67 and PCNA as well as with conventional clinicopathological variables. CD44s immunoreactivity was detected in 47.6% of the cases. The incidence of CD44s expression did not differ among histological types of carcinomas. CD44s expression was significantly related to depth of invasion (p=0.03) and to Ki-67 positive rate (p=0.018). A trend for correlation with vessel invasion was also observed (p=0.06). The relation of CD44 expression with the other studied variables was insignificant. These data suggest that CD44s may have a major role as adhesion molecule in the progression of gastric carcinomas. In addition, the expression of CD44s is associated with proliferation, suggesting that in gastric cancer CD44s may have a role in tumor cell growth.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondary<Go to ISI>://WOS:000087559500006-
heal.journalNameJournal of Tumor Marker Oncologyen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2000-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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