Energy Loss of Hydrogen- and Helium-Ion Beams in DNA: Calculations Based on a Realistic Energy-Loss Function of the Target
| dc.contributor.author | Abril, I. | en |
| dc.contributor.author | Garcia-Molina, R. | en |
| dc.contributor.author | Denton, C. D. | en |
| dc.contributor.author | Kyriakou, I. | en |
| dc.contributor.author | Emfietzoglou, D. | en |
| dc.date.accessioned | 2015-11-24T19:19:19Z | |
| dc.date.available | 2015-11-24T19:19:19Z | |
| dc.identifier.issn | 1938-5404 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/21951 | |
| dc.rights | Default Licence | - |
| dc.title | Energy Loss of Hydrogen- and Helium-Ion Beams in DNA: Calculations Based on a Realistic Energy-Loss Function of the Target | en |
| heal.abstract | Abstract We have calculated the electron energy loss of proton and alpha-particle beams in dry DNA using the dielectric formalism. The electron response of DNA is described by the MELF-GOS model, in which the outer electron excitations of the target are accounted for by a linear combination of Mermin-type energy-loss functions that accurately matches the available experimental data for DNA obtained from optical measurements, whereas the inner-shell electron excitations are modeled by the generalized oscillator strengths of the constituent atoms. Using this procedure we have calculated the stopping power and the energy-loss straggling of DNA for hydrogen- and helium-ion beams at incident energies ranging from 10 keV/nucleon to 10 MeV/nucleon. The mean excitation energy of dry DNA is found to be I = 81.5 eV. Our present results are compared with available calculations for liquid water showing noticeable differences between these important biological materials. We have also evaluated the electron excitation probability of DNA as a function of the transferred energy by the swift projectile as well as the average energy of the target electronic excitations as a function of the particlesenergy. Our results show that projectiles with energy less, similar100 keV/nucleon (i.e., around the stopping-power maximum) are more suitable for producing low-energy secondary electrons in DNA, which could be very effective for the biological damage of malignant cells. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/21039284 | - |
| heal.journalName | Radiat Res | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2010 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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