Effects and clinical significance of GnRH antagonist administration for IUI timing in FSH superovulated cycles: a meta-analysis

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dc.contributor.authorKosmas, I. P.en
dc.contributor.authorTatsioni, A.en
dc.contributor.authorKolibianakis, E. M.en
dc.contributor.authorVerpoest, W.en
dc.contributor.authorTournaye, H.en
dc.contributor.authorVan der Elst, J.en
dc.contributor.authorDevroey, P.en
dc.date.accessioned2015-11-24T19:21:57Z
dc.date.available2015-11-24T19:21:57Z
dc.identifier.issn1556-5653-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22134
dc.rightsDefault Licence-
dc.subjectFemaleen
dc.subjectGonadotropin-Releasing Hormone/administration & dosage/analogs &en
dc.subjectderivatives/*antagonists & inhibitorsen
dc.subjectHormone Antagonists/*administration & dosageen
dc.subjectHumansen
dc.subjectInsemination, Artificial/methodsen
dc.subjectOvulation Induction/*methodsen
dc.subjectPregnancyen
dc.subject*Pregnancy Rateen
dc.subjectRandomized Controlled Trials as Topicen
dc.subjectTime Factorsen
dc.titleEffects and clinical significance of GnRH antagonist administration for IUI timing in FSH superovulated cycles: a meta-analysisen
heal.abstractOBJECTIVES: To compare the administration of GnRH antagonist in gonadotropin intrauterine insemination (IUI) cycles with cycles where no intervention took place. DESIGN: Meta-analysis of published prospective randomized trials. PATIENTS(S): Five hundred twenty-one patients who were administered a GnRH antagonist and 548 conservatively treated patients who served as control subjects were included in the meta-analysis. INTERVENTION(S): Study selection: Prospective trials were retrieved from Medline and Cochrane Library (last update October 2006). Random effect analysis was used in this meta-analysis. Two independent reviewers performed data extraction. MAIN OUTCOME MEASURE(S): Clinical pregnancy rates. RESULT(S): Six comparisons were retrieved including 1,069 patients. Higher pregnancy rates were found in the randomized controlled trials (odds ratio [OR] 1.56, 95% confidence interval [CI] 1.05-2.33) when a GnRH antagonist was added to a gonadotropin superovulated IUI protocol. Early published studies with smaller sample sizes showed stronger associations (OR 2.31, 95% CI 1.15-4.63) than later studies (OR 1.32, 95% CI 0.79-2.23). CONCLUSION(S): From the randomized controlled trials of this meta-analysis, it is clear that allowing for follicle growth and avoiding premature LH rise, increased pregnancy rates are observed with GnRH antagonist administration. A parallel trend for multiple pregnancy rates in the GnRH antagonist group was observed, although this did not reach statistical significance. The flexible regimen was widely used. This meta-analysis of early data might enhance further research in this direction.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.fertnstert.2007.06.064-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17936285-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0015028207014252/1-s2.0-S0015028207014252-main.pdf?_tid=a153ed97032af5fed4e463e40df4e29a&acdnat=1334039782_2f22cc283c75bc37136f732ae5aea1b9-
heal.journalNameFertil Sterilen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2008-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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