Involvement of adenosine A1 and A2A receptors in the adenosinergic modulation of the discriminative-stimulus effects of cocaine and methamphetamine in rats

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dc.contributor.authorJustinova, Z.en
dc.contributor.authorFerre, S.en
dc.contributor.authorSegal, P. N.en
dc.contributor.authorAntoniou, K.en
dc.contributor.authorSolinas, M.en
dc.contributor.authorPappas, L. A.en
dc.contributor.authorHighkin, J. L.en
dc.contributor.authorHockemeyer, J.en
dc.contributor.authorMunzar, P.en
dc.contributor.authorGoldberg, S. R.en
dc.date.accessioned2015-11-24T19:09:01Z
dc.date.available2015-11-24T19:09:01Z
dc.identifier.issn0022-3565-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20636
dc.rightsDefault Licence-
dc.subjectAdenosine/*analogs & derivatives/pharmacology/*physiologyen
dc.subjectAdenosine A1 Receptor Agonistsen
dc.subjectAdenosine A1 Receptor Antagonistsen
dc.subjectAdenosine A2 Receptor Agonistsen
dc.subjectAdenosine A2 Receptor Antagonistsen
dc.subjectAnimalsen
dc.subjectCentral Nervous System Stimulants/*pharmacologyen
dc.subjectCocaine/*pharmacologyen
dc.subjectConditioning, Operant/drug effectsen
dc.subjectDiscrimination (Psychology)/*drug effectsen
dc.subjectDiscrimination Learning/drug effectsen
dc.subjectDose-Response Relationship, Drugen
dc.subjectGeneralization (Psychology)en
dc.subjectMaleen
dc.subjectMethamphetamine/*pharmacologyen
dc.subjectPhenethylamines/pharmacologyen
dc.subjectRatsen
dc.subjectRats, Sprague-Dawleyen
dc.subjectReceptor, Adenosine A1/*metabolismen
dc.subjectReceptor, Adenosine A2A/*metabolismen
dc.subjectTheophylline/*analogs & derivatives/pharmacologyen
dc.subjectXanthines/pharmacologyen
dc.titleInvolvement of adenosine A1 and A2A receptors in the adenosinergic modulation of the discriminative-stimulus effects of cocaine and methamphetamine in ratsen
heal.abstractAdenosine, by acting on adenosine A1 and A2A receptors, is known to antagonistically modulate dopaminergic neurotransmission. We have recently reported that nonselective adenosine receptor antagonists (caffeine and 3,7-dimethyl-1-propargylxanthine) can partially substitute for the discriminative-stimulus effects of methamphetamine. In the present study, by using more selective compounds, we investigated the involvement of A1 and A2A receptors in the adenosinergic modulation of the discriminative-stimulus effects of both cocaine and methamphetamine. The effects of the A1 receptor agonist N6-cyclopentyladenosine (CPA; 0.01-0.1 mg/kg) and antagonist 8-cyclopentyl-1,3-dimethylxanthine (CPT; 1.3-23.7 mg/kg) and the A2A receptor agonist 2-p-(2-carboxyethyl)phenethylamino-5'-N-ethylcarboxamidoadenosine hydrochloride (CGS 21680; 0.03-0.18 mg/kg) and antagonist 3-(3-hydroxypropyl)-8-(3-methoxystyryl)-7-methyl-1-propargylxanthin phosphate disodium salt (MSX-3; 1-56 mg/kg) were evaluated in rats trained to discriminate either 1 mg/kg methamphetamine or 10 mg/kg cocaine from saline under a fixed-ratio 10 schedule of food presentation. The A1 and A2A receptor antagonists (CPT and MSX-3) both produced high levels of drug-lever selection when substituted for either methamphetamine or cocaine and significantly shifted dose-response curves of both psychostimulants to the left. Unexpectedly, the A2A receptor agonist CGS 21680 also produced drug-appropriate responding (although at lower levels) when substituted for the cocaine-training stimulus, and both CGS 21680 and the A1 receptor agonist CPA significantly shifted the cocaine dose-response curve to the left. In contrast, both agonists did not produce significant levels of drug-lever selection when substituted for the methamphetamine-training stimulus and failed to shift the methamphetamine dose-response curve. Therefore, adenosine A1 and A2A receptors appear to play important but differential roles in the modulation of the discriminative-stimulus effects of methamphetamine and cocaine.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1124/jpet.103.056762-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/14557381-
heal.identifier.secondaryhttp://jpet.aspetjournals.org/content/307/3/977.full.pdf-
heal.journalNameJ Pharmacol Exp Theren
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2003-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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