A randomized controlled trial of pentoxifylline for the prevention of post-ERCP pancreatitis
Φόρτωση...
Ημερομηνία
Συγγραφείς
Kapetanos, D.
Kokozidis, G.
Christodoulou, D.
Mistakidis, K.
Sigounas, D.
Dimakopoulos, K.
Kitis, G.
Tsianos, E. V.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Gastrointest Endosc
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
BACKGROUND: Pentoxifylline can ameliorate pancreatitis in animal models because of its anti-tumor necrosis factor properties. OBJECTIVE: Our purpose was to study the safety and efficacy of pentoxifylline in the prevention of post-ERCP pancreatitis. DESIGN: Patients due to undergo ERCP for various indications were randomized to receive pentoxifylline 400 mg orally 3 times, beginning the day before ERCP (2 and 10 pm) until the night after the procedure (6 am and 2 and 10 pm) or to receive no preventive medication. Serum amylase values were determined before and 6 and 24 hours after ERCP. Diagnosis and grading of the severity of complications was performed according to consensus criteria. PATIENTS: One hundred fifty-eight patients received pentoxifylline (group A) and 162 had no medication (group B). The groups were similar in distributions of sex, biliary sphincterotomy, pancreatography, pancreatic duct cannulations, stone extraction, stent placement, and presence of periampullary diverticulum. Group A patients were younger (mean age 63 vs 68 years, P<.05) and biliary colic was a more frequent indication (30 vs 12, P<.05). RESULTS: Nine (5.6%) patients in group A and 5 (3%) in group B had pancreatitis (2 and 1 severe, respectively; P=.28). Serum amylase values were similar in baseline and 6- and 24-hour samples. Two (1.2%) patients in group A and 7 (4.3%) in group B had hemorrhage. LIMITATIONS: This was not a double-blind trial. CONCLUSIONS: In this study pentoxifylline did not protect against post-ERCP pancreatitis or hyperamylasemia.
Περιγραφή
Λέξεις-κλειδιά
Aged, Bile Duct Diseases/diagnosis/*therapy, Cholangiopancreatography, Endoscopic Retrograde/*adverse effects, Female, Humans, Hyperamylasemia/prevention & control, Male, Middle Aged, Pancreatitis/*prevention & control, Pentoxifylline/*therapeutic use, *Premedication, Sphincterotomy, Endoscopic/adverse effects
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/17725940
http://ac.els-cdn.com/S0016510707015805/1-s2.0-S0016510707015805-main.pdf?_tid=ab6c1fd6edfcde3f1f39b3c11468c003&acdnat=1333960569_2aed7b37ad32fa51bb88d35594ab8156
http://ac.els-cdn.com/S0016510707015805/1-s2.0-S0016510707015805-main.pdf?_tid=ab6c1fd6edfcde3f1f39b3c11468c003&acdnat=1333960569_2aed7b37ad32fa51bb88d35594ab8156
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής