Parathormone and 1,25(OH)2D3 but not 25(OH)D3 serum levels, in an inverse correlation, reveal an association with advanced stages of colorectal cancer

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dc.contributor.authorCharalampopoulos, A.en
dc.contributor.authorCharalabopoulos, A.en
dc.contributor.authorBatistatou, A.en
dc.contributor.authorGolias, C.en
dc.contributor.authorAnogeianaki, A.en
dc.contributor.authorPeschos, D.en
dc.contributor.authorIliadis, I.en
dc.contributor.authorMacheras, A.en
dc.contributor.authorCharalabopoulos, K.en
dc.date.accessioned2015-11-24T19:00:02Z
dc.date.available2015-11-24T19:00:02Z
dc.identifier.issn1591-9528-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19464
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectCalcifediol/*blooden
dc.subjectCalcitriol/*blooden
dc.subjectColorectal Neoplasms/*pathologyen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectParathyroid Hormone/*blooden
dc.subjectSeverity of Illness Indexen
dc.titleParathormone and 1,25(OH)2D3 but not 25(OH)D3 serum levels, in an inverse correlation, reveal an association with advanced stages of colorectal canceren
heal.abstractExperimental, epidemiologic, and clinical trial data indicate the antineoplastic effects of calcium and vitamin D in large-bowel neoplasia. The aim of this study was to determine serum levels of vitamin D metabolites and parathormone (PTH) in patients with colorectal cancer (CRC) and to extract conclusions comparing their different levels in serum with healthy individuals. Group 1 (cancer patients) was consisted of 140 patients with CRC with clinical stages Duke's A: 12, B: 52, C: 62, and D: 14. Serum levels of 25(OH)D(3), 1,25(OH)(2)D(3), and PTH were determined in all patients. The findings are: (a) No significant difference was found in the serum levels of 25(OH)D(3) in each Duke's clinical stage in cancer patients, (b) serum 1,25(OH)(2)D(3) levels decreased with advanced cancer stages, and (c) serum levels of PTH showed a corresponding increase. Low serum levels of 1,25(OH)(2)D(3) on one hand and increased levels of PTH in patients with CRC on the other might be strongly related to the carcinogenetic process.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1007/s10238-009-0069-6-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/19779960-
heal.identifier.secondaryhttp://www.springerlink.com/content/wg44663947rh1884/fulltext.pdf-
heal.journalNameClin Exp Meden
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2010-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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