Langerhans cells and lymphocyte subsets in human gastrointestinal carcinomas. An immunohistological study on frozen sections

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dc.contributor.authorPapadimitriou, C. S.en
dc.contributor.authorDatseris, G.en
dc.contributor.authorCostopoulos, J. S.en
dc.contributor.authorBai, M. K.en
dc.contributor.authorIoachim-Velogianni, E.en
dc.contributor.authorKatsouyannopoulos, V.en
dc.date.accessioned2015-11-24T19:08:12Z
dc.date.available2015-11-24T19:08:12Z
dc.identifier.issn0344-0338-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20507
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectAntibodies, Monoclonalen
dc.subjectCarcinoma/chemistry/*pathologyen
dc.subjectColorectal Neoplasms/chemistry/*pathologyen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectLangerhans Cells/*pathologyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectS100 Proteins/analysisen
dc.subjectStomach Neoplasms/chemistry/*pathologyen
dc.subjectT-Lymphocytes, Helper-Inducer/*pathologyen
dc.subjectT-Lymphocytes, Regulatory/*pathologyen
dc.titleLangerhans cells and lymphocyte subsets in human gastrointestinal carcinomas. An immunohistological study on frozen sectionsen
heal.abstractIn an immunohistochemical study of 38 human gastric and 40 human colonic carcinomas Langerhans cells, suppressor and helper lymphocytes were identified on frozen sections by using anti-CD1, anti-CD8 and anti-CD4 monoclonal antibodies. Tumours were divided into those with few (< 3 per high power field) and those with many (> 3 per high power field) Langerhans cells as well as into those with high number of CD4 and CD8 cells (> 30 per high power field). No significant difference in the number of Langerhans cells regarding histologic types, degree of differentiation and metastatic/non-metastatic groups of either gastric or colonic carcinomas was found. On the contrary the numbers of Langerhans cells related significantly (p < 0.05) to density of T-cell and especially CD4 cell infiltrations of gastric and colonic carcinomas. This finding supports the role of Langerhans cells as antigen presenting cells and their involvement in T-cell activation against neoplastic cells of human gastrointestinal carcinomas.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/1300611-
heal.journalNamePathol Res Practen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1992-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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