Effects of CCR5-Delta32 and CCR2-64I alleles on HIV-1 disease progression: the protection varies with duration of infection

Απλή σελίδα τεκμηρίου
dc.contributor.authorMulherin, S. A.en
dc.contributor.authorO'Brien, T. R.en
dc.contributor.authorIoannidis, J. P.en
dc.contributor.authorGoedert, J. J.en
dc.contributor.authorBuchbinder, S. P.en
dc.contributor.authorCoutinho, R. A.en
dc.contributor.authorJamieson, B. D.en
dc.contributor.authorMeyer, L.en
dc.contributor.authorMichael, N. L.en
dc.contributor.authorPantaleo, G.en
dc.contributor.authorRizzardi, G. P.en
dc.contributor.authorSchuitemaker, H.en
dc.contributor.authorSheppard, H. W.en
dc.contributor.authorTheodorou, I. D.en
dc.contributor.authorVlahov, D.en
dc.contributor.authorRosenberg, P. S.en
dc.date.accessioned2015-11-24T19:21:39Z
dc.date.available2015-11-24T19:21:39Z
dc.identifier.issn0269-9370-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22115
dc.rightsDefault Licence-
dc.subjectAcquired Immunodeficiency Syndrome/*geneticsen
dc.subjectDisease Progressionen
dc.subjectHIV Seropositivity/geneticsen
dc.subjectHIV-1/*geneticsen
dc.subjectHeterozygoteen
dc.subjectHumansen
dc.subjectPolymorphism, Genetic/geneticsen
dc.subjectProportional Hazards Modelsen
dc.subjectReceptors, CCR2en
dc.subjectReceptors, CCR5/*geneticsen
dc.subjectReceptors, Chemokine/*geneticsen
dc.subjectSurvival Analysisen
dc.subjectTime Factorsen
dc.titleEffects of CCR5-Delta32 and CCR2-64I alleles on HIV-1 disease progression: the protection varies with duration of infectionen
heal.abstractOBJECTIVE: To examine temporal variation in the effects of CCR5-Delta32 and CCR2-64I chemokine receptor gene polymorphisms on HIV-1 disease progression. DESIGN: Pooled analysis of individual patient data from 10 cohorts of HIV-1 seroconverters from the United States, Europe, and Australia. METHODS: We studied HIV-1 seroconverters of European (n = 1635) or African (n = 215) ancestry who had been genotyped for CCR5-Delta32 and CCR2-64I. We used Cox proportional hazards models with time-varying coefficients to determine whether the genetic protection against AIDS (1987 case definition) and death varied with time since seroconversion. RESULTS: Protection against AIDS conferred by CCR5-Delta32 held constant at a 31% (RH 0.69, 95% CI 0.54, 0.88) reduction in risk over the course of HIV-1 infection, whereas protection against death held constant at a 39% reduction in risk (RH 0.61, 95% CI 0.45, 0.88). When the period from AIDS to death was isolated, the survival benefit of CCR5-Delta32 diminished 2 years after AIDS. Protection against AIDS conferred by CCR2-64I was greatest early in the disease course. Compared with individuals without CCR5-Delta32 or CCR2-64I, individuals with one or two copies of CCR2-64I had a 58% lower risk of AIDS during the first 4 years after seroconversion (RH 0.42, 95% CI 0.23, 0.76), a 19% lower risk during the subsequent 4 years (RH 0.81, 95% CI 0.59, 1.12), and no significant protection thereafter. CONCLUSION: The protection against AIDS provided by CCR5-Delta32 is continuous during the course of infection. In contrast, the protection provided by CCR2-64I is greatest early in the course of infection.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1097/01.aids.0000050783.28043.3e-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/12556692-
heal.journalNameAIDSen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2003-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ