Poly(A)-polymerase activity in chronic lymphocytic leukemia of the B cell type
| dc.contributor.author | Pangalis, G. A. | en |
| dc.contributor.author | Trangas, T. | en |
| dc.contributor.author | Papanastasiou, C. J. | en |
| dc.contributor.author | Roussou, P. A. | en |
| dc.contributor.author | Tsiapalis, C. M. | en |
| dc.date.accessioned | 2015-11-24T16:34:56Z | |
| dc.date.available | 2015-11-24T16:34:56Z | |
| dc.identifier.issn | 0001-5792 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/7876 | |
| dc.rights | Default Licence | - |
| dc.subject | *B-Lymphocytes/analysis/pathology | en |
| dc.subject | Bone Marrow/pathology | en |
| dc.subject | Humans | en |
| dc.subject | Leukemia, Lymphoid/classification/*enzymology/pathology | en |
| dc.subject | Nucleotidyltransferases/*metabolism | en |
| dc.subject | Polynucleotide Adenylyltransferase/*metabolism | en |
| dc.subject | Tissue Extracts | en |
| dc.title | Poly(A)-polymerase activity in chronic lymphocytic leukemia of the B cell type | en |
| heal.abstract | Poly(A)-polymerase enzymic activity was biochemically determined in lymphocytic extracts from 40 patients with chronic lymphocytic leukemia of the B cell type. The enzymic activities of patients with stage A, B and C disease were (U/mg of protein): 4.9 +/- 5.5, 12.5 +/- 7.5 and 20.9 +/- 18.9, respectively. The difference in the enzyme level between stage A and C patients was statistically significant (p less than 0.05). Comparison of the enzyme activity level in relation to the pattern of bone marrow involvement revealed that patients with a diffuse pattern of infiltration had a significantly higher enzyme level (17.9 +/- 15.5 U/mg of protein) than patients with interstitial or mixed infiltration patterns (5.9 +/- 6.6 and 7.9 +/- 7.0 U/mg of protein; p less than 0.025). Finally, patients who required treatment for their disease also had a significantly higher poly(A)-polymerase activity level (14.5 +/- 13.9 U/mg of protein) than patients with stable disease (4.9 +/- 5.5 U/mg of protein; p less than 0.05). Our results indicate that the enzyme poly(A)-polymerase may be used as a biological marker in patients with chronic lymphocytic leukemia. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/3000122 | - |
| heal.journalName | Acta Haematol | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1985 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιών | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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