Obstetric and gynaecological profile in patients with primary Sjogren's syndrome

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dc.contributor.authorSkopouli, F. N.en
dc.contributor.authorPapanikolaou, S.en
dc.contributor.authorMalamou-Mitsi, V.en
dc.contributor.authorPapanikolaou, N.en
dc.contributor.authorMoutsopoulos, H. M.en
dc.date.accessioned2015-11-24T19:01:17Z
dc.date.available2015-11-24T19:01:17Z
dc.identifier.issn0003-4967-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19668
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAge Factorsen
dc.subjectAgeden
dc.subjectCoitusen
dc.subjectDyspareunia/*etiologyen
dc.subjectFemaleen
dc.subjectFertilityen
dc.subjectHumansen
dc.subjectMenopauseen
dc.subjectMenstrual Cycleen
dc.subjectMiddle Ageden
dc.subjectParityen
dc.subjectPregnancyen
dc.subjectPregnancy Outcomeen
dc.subject*Reproductive Historyen
dc.subjectSjogren's Syndrome/complications/pathology/*physiopathologyen
dc.subjectTime Factorsen
dc.subjectVagina/pathologyen
dc.titleObstetric and gynaecological profile in patients with primary Sjogren's syndromeen
heal.abstractOBJECTIVE: To describe the effects of Sjogren's syndrome (SS) on the fertility, parity and sexual activity as well as investigating the aetiopathology of dyspareunia in female patients. METHODS: Fifty one female patients with primary SS (pSS) and 57 healthy controls were interviewed concerning their past gynaecological, obstetric and sexual history and underwent a complete gynaecological examination. Punch biopsy of the vagina was performed in six patients and one healthy individual. In addition, the vaginal tissue was evaluated following hysterectomy in two patients with pSS. RESULTS: No differences were observed in fertility, parity or reproductive success rate between patients and controls. Atrophy of the external genitalia and production of cervical mucus in both patients and controls correlated with age and menopause, but not with other clinical or serological pSS manifestations. Dyspareunia was observed in 40% of the patients during the premenopause period compared with 3% observed in controls. Half of the patients, however, had an obvious aetiology for dyspareunia (trauma or inflammation) not related to pSS. The histological picture of the patients' vaginal tissue revealed perivascular infiltration. Finally, pSS patients appeared to have a similar intercourse frequency with the controls. However, unlike that observed in controls, the intercourse frequency did not diminish with age nor with the presence of dyspareunia. CONCLUSION: The fertility, parity and sexual activity of pSS patients does not appear to differ from that of the healthy population. Dyspareunia is a frequent symptom in these patients and local perivascular in these patients and local perivascular inflammation may contribute to the expression of this manifestation.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/7979594-
heal.identifier.secondaryhttp://ard.bmj.com/content/53/9/569.full.pdf-
heal.journalNameAnn Rheum Disen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1994-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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