Primary extranodal non Hodgkin's lymphoma of the head and neck in adults: a clinicopathological comparison between tonsillar and non tonsillar lymphomas. (Hellenic co-Operative Oncology Group)

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dc.contributor.authorEconomopoulos, T.en
dc.contributor.authorFountzilas, G.en
dc.contributor.authorKostourou, A.en
dc.contributor.authorDaniilidis, J.en
dc.contributor.authorPavlidis, N.en
dc.contributor.authorAndreopoulou, H.en
dc.contributor.authorNicolaou, A.en
dc.contributor.authorPapageorgiou, E.en
dc.contributor.authorMellou, S.en
dc.contributor.authorDervenoulas, J.en
dc.contributor.authorStathakis, N.en
dc.date.accessioned2015-11-24T18:56:36Z
dc.date.available2015-11-24T18:56:36Z
dc.identifier.issn0250-7005-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19067
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAntineoplastic Combined Chemotherapy Protocols/*therapeutic useen
dc.subjectCombined Modality Therapyen
dc.subjectCyclophosphamide/administration & dosageen
dc.subjectDisease-Free Survivalen
dc.subjectDoxorubicin/administration & dosageen
dc.subjectEpirubicin/administration & dosageen
dc.subjectFemaleen
dc.subjectGreeceen
dc.subjectHead and Neck Neoplasms/*drug therapy/mortality/pathology/*radiotherapyen
dc.subjectHumansen
dc.subjectHydrocortisone/administration & dosageen
dc.subjectLymphoma, Non-Hodgkin/*drug therapy/mortality/pathology/*radiotherapyen
dc.subjectMaleen
dc.subjectMethotrexate/administration & dosageen
dc.subjectMethylprednisolone/administration & dosageen
dc.subjectMiddle Ageden
dc.subjectMitoxantrone/administration & dosageen
dc.subjectMultivariate Analysisen
dc.subjectNeoplasm Stagingen
dc.subjectPrednisolone/administration & dosageen
dc.subjectPrednisone/administration & dosageen
dc.subjectRecurrenceen
dc.subjectSurvival Rateen
dc.subjectTime Factorsen
dc.subjectVincristine/administration & dosageen
dc.titlePrimary extranodal non Hodgkin's lymphoma of the head and neck in adults: a clinicopathological comparison between tonsillar and non tonsillar lymphomas. (Hellenic co-Operative Oncology Group)en
heal.abstractPrimary extranodal NHL of the head and neck (HN-NHL) accounts for 10-20% of all cases of NHL. Despite their frequency, the natural history and biological behaviour of these lymphomas is poorly understood. In this study we analysed the data 116 cases of HN-NHL. There were 65 males and 51 females with a median age of 56 years. The distribution among different anatomical sites was: tonsils 56 cases (48.3%), nasopharynx 15 (12.9%), mandible/gingiva 9 (7.8%), hard palate 7 (6%), parotis 6 (5.2%), nasal cavity 6 (5.2%), hypopharynx/larynx 6 (5.2%), thyroid 5 (4.3%), ocular adnexa 4 (3.5%), paranasal sinuses 2 (1.7%). The patients were treated with radiotherapy alone (14 cases), combined chemotherapy (52 cases) and combined modality (50 cases). According to the WF histological classification 73 cases (62.9%) had intermediate, 32 (27.6%) high and 11 (9.5%) low grade. Patients were separated in two groups: Tonsillar NHL (56 cases) and NHL of all other sites (non-tonsillar group-60 cases). A comparison between the two groups showed that there was no statistically significant difference with respect to age, sex, and histological subtypes. Also treatment response was similar (82.1% for the tonsillar vs 83.3% for the non-tonsillar). The two groups differed in stage distribution, survival and pattern of relapse. Stage I was more frequent in the non-tonsillar NHL (60%) in contrast to tonsillar NHL where stage II was more prominent (51.8%). Median survival was 86 months for the tonsillar while it has not been reached yet for the non-tonsillar patients. Patients in stage I and stage II of the non-tonsillar group had better survival compared to stages I and II of the tonsillar patients. Finally GI tract was a common site of relapse in the tonsillar group while a considerable number in CNS relapses were observed in the non-tonsillar group. We concluded that HN-NHL constitutes a heterogeneous group of patients. Tonsillar lymphomas represent a distinct group with some special clinicopathological findings.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/9891536-
heal.journalNameAnticancer Resen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1998-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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