Influence of growth factors erythropoietin and granulocyte macrophage colony stimulating factor on mechanical strength and healing of colonic anastomoses in rats
| dc.contributor.author | Fatouros, M. S. | en |
| dc.contributor.author | Vekinis, G. | en |
| dc.contributor.author | Bourantas, K. L. | en |
| dc.contributor.author | Mylonakis, E. P. | en |
| dc.contributor.author | Scopelitou, A. S. | en |
| dc.contributor.author | Malamou-Mitsis, V. D. | en |
| dc.contributor.author | Kappas, A. M. | en |
| dc.date.accessioned | 2015-11-24T19:10:03Z | |
| dc.date.available | 2015-11-24T19:10:03Z | |
| dc.identifier.issn | 1102-4151 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/20782 | |
| dc.rights | Default Licence | - |
| dc.subject | Anastomosis, Surgical/*methods | en |
| dc.subject | Animals | en |
| dc.subject | Colon/pathology/*surgery | en |
| dc.subject | Erythropoietin/*physiology | en |
| dc.subject | Granulocyte-Macrophage Colony-Stimulating Factor/*physiology | en |
| dc.subject | Male | en |
| dc.subject | Rats | en |
| dc.subject | Rats, Wistar | en |
| dc.subject | Tensile Strength | en |
| dc.subject | Wound Healing/*physiology | en |
| dc.title | Influence of growth factors erythropoietin and granulocyte macrophage colony stimulating factor on mechanical strength and healing of colonic anastomoses in rats | en |
| heal.abstract | OBJECTIVE: To find out what influence erythropoietin and granulocyte macrophage colony stimulating factor (GM-CSF) had on the healing of left colonic anastomoses in rats. DESIGN: Experimental study. SETTING: University hospital of Ioannina, Greece. ANIMALS: 40 rats. INTERVENTIONS: An end to end anastomosis was created in the left colon. The rats in the experimental groups were treated with erythropoietin, or GM-CSF, or the two in combination. MAIN OUTCOME MEASURES: Tensile breaking strength of the anastomosis, histological characteristics of the anastomosed segment, changes in body weight, and packed cell volume (PCV) during the experiment. RESULTS: The tensile breaking strength of the anastomosis on the seventh postoperative day was significantly greater in the erythropoietin group (mean 2.8N, 95% confidence interval (CI) 0.12N, p 0.0004) than in the control group (mean 1.60N, 95% CI 0.12N). It did not differ from the GM-CSF groups (mean 1.67N, 95% CI 0.21N, p 0.68) or erythropoietin GM-CSF (mean 1.67N, 95% CI 0.11N, p 0.44). The PCV was significantly higher in the two groups given erythropoietin (p < 0.001) but not in the GM-CSF group (p 0.8) while that in the control group was significantly lower (p < 0.001). The body weight followed the same pattern, being significantly more in the two groups given erythropoietin (p = 0.03 and 0.003) but not in controls (p = 0.09) or the GM-CSF group (p = 0.2). CONCLUSIONS: Erythropoietin enhances the healing of anastomosis in rat colon by increasing the number of fibroblasts and accelerating the maturation of new vessels. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1080/110241599750008143 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/10574109 | - |
| heal.journalName | Eur J Surg | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1999 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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