Lack of association of birth size with polymorphisms of two imprinted genes, IGF2R and GRB10

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dc.contributor.authorKukuvitis, A.en
dc.contributor.authorGeorgiou, I.en
dc.contributor.authorSyrrou, M.en
dc.contributor.authorAndronikou, S.en
dc.contributor.authorDickerman, Z.en
dc.contributor.authorIslam, A.en
dc.contributor.authorMcCann, J.en
dc.contributor.authorPolychronakos, C.en
dc.date.accessioned2015-11-24T19:08:22Z
dc.date.available2015-11-24T19:08:22Z
dc.identifier.issn0334-018X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20522
dc.rightsDefault Licence-
dc.subjectAllelesen
dc.subjectBase Sequenceen
dc.subject*Birth Weighten
dc.subjectCohort Studiesen
dc.subjectFemaleen
dc.subjectFetal Blooden
dc.subjectFollow-Up Studiesen
dc.subjectGRB10 Adaptor Proteinen
dc.subjectGene Expression Regulationen
dc.subject*Genomic Imprintingen
dc.subjectHumansen
dc.subjectInfant, Newbornen
dc.subjectMaleen
dc.subjectMolecular Sequence Dataen
dc.subjectPolymerase Chain Reactionen
dc.subject*Polymorphism, Geneticen
dc.subjectProteins/*geneticsen
dc.subjectReceptor, IGF Type 2/*geneticsen
dc.subjectTerm Birthen
dc.titleLack of association of birth size with polymorphisms of two imprinted genes, IGF2R and GRB10en
heal.abstractLittle is known about the determinants of birth size variability among individuals. Maternal and nutritional factors have been studied, but familial clustering suggests genetic factors as well. As a first step in testing this hypothesis, we examined common sequence variants in IGF2R and GRB10, two genes involved in the regulation of growth and subject to parental imprinting. The IGF2R gene was scanned with five polymorphisms spanning the coding and 3'-UTR for possible association with birth size in a set of 97 normal newborns in Greece. In addition, a silent SNP in GRB10 exon 2 was similarly tested as an exploratory first step. Birth weight and length were compared between groups of newborns divided according to which allele they had received from heterozygous parents. No significant differences were found between alleles in either gene, examined either by parental origin or in aggregate. Thus, we found no evidence that IGF2R variants modulate intrauterine growth within the normal range. If such variants exist in GRB10, they are not in linkage disequilibrium with the marker studied.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15506681-
heal.identifier.secondaryhttp://www.degruyter.com/view/j/jpem.2004.17.9/jpem.2004.17.9.1215/jpem.2004.17.9.1215.xml-
heal.journalNameJ Pediatr Endocrinol Metaben
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2004-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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