Crohn's disease incidence evolution in North-western Greece is not associated with alteration of NOD2/CARD15 variants

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dc.contributor.authorEconomou, M.en
dc.contributor.authorFilis, G.en
dc.contributor.authorTsianou, Z.en
dc.contributor.authorAlamanos, J.en
dc.contributor.authorKogevinas, A.en
dc.contributor.authorMasalas, K.en
dc.contributor.authorPetrou, A.en
dc.contributor.authorTsianos, E. V.en
dc.date.accessioned2015-11-24T19:26:16Z
dc.date.available2015-11-24T19:26:16Z
dc.identifier.issn1007-9327-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22707
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectColitis, Ulcerative/epidemiology/geneticsen
dc.subjectCrohn Disease/*epidemiology/ethnology/*geneticsen
dc.subjectFemaleen
dc.subjectGenetic Predisposition to Disease/geneticsen
dc.subjectGreece/epidemiologyen
dc.subjectHumansen
dc.subjectIncidenceen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectMutation/geneticsen
dc.subjectNod2 Signaling Adaptor Protein/*geneticsen
dc.titleCrohn's disease incidence evolution in North-western Greece is not associated with alteration of NOD2/CARD15 variantsen
heal.abstractAIM: To assess the trends in the incidence of inflammatory bowel disease (IBD) over 23 years in the same area and to identify genetic factors related to incidence evolution. METHODS: Patients with IBD arising from North-western Greece were systematically recorded through the 1983-2005 period. Trends in disease incidence and genetic patterns related to CARD15 variants were documented and correlated. RESULTS: A total of 447 patients with IBD were recorded (23.5% Crohn's disease, 72.7% Ulcerative colitis and 3.8% indeterminate colitis). Mean annual incidence rates of CD and UC were 0.9/100,000 (95% CI 0.1-1.7) and 2.7/100,000 (95% CI 1.7-4.1) inhabitants, respectively. There was a statistically significant increase of CD incidence (P<0.01) during the study period, in contrast to the UC incidence. There were no statistical differences in CARD15 variants over the study period. CONCLUSION: The incidence of CD in North-western Greece has risen disproportionately to that of UC in the 21st century. This is not related to alterations of genetic background though.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17876878-
heal.journalNameWorld J Gastroenterolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2007-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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