Continuous infusion of N-acetylcysteine reduces liver warm ischaemia-reperfusion injury
Φόρτωση...
Ημερομηνία
Συγγραφείς
Glantzounis, G. K.
Yang, W.
Koti, R. S.
Mikhailidis, D. P.
Seifalian, A. M.
Davidson, B. R.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Br J Surg
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
BACKGROUND: N-acetylcysteine (NAC) may modulate the initial phase (less than 2 h) of liver warm ischaemia-reperfusion (IR) injury but its effect on the late phase remains unclear. The present study investigated the role of NAC during the early and late phases in a rabbit lobar IR model. METHODS: Liver ischaemia was induced by inflow occlusion to the median and left liver lobes for 60 min, followed by 7 h of reperfusion. In the NAC group (n = 6), NAC was administered intravenously at 150 mg per kg over the 15 min before reperfusion and maintained at 10 mg per kg per h during reperfusion. In the IR group (n = 6), 20 ml 5 per cent dextrose was infused over the 15 min before reperfusion and continued at a rate of 10 ml/h. Animals in a sham operation group (n = 6) underwent laparotomy but no liver ischaemia. All animals were killed at the end of the experiment. RESULTS: Intracellular tissue oxygenation was improved after the second hour of reperfusion in animals treated with NAC compared with that in the IR group (P = 0.023). Hepatic microcirculation improved after 5 h of reperfusion (P = 0.036) and liver injury was reduced after 5 h, as indicated by alanine aminotransferase activity (P = 0.007) and indocyanine green clearance (uptake, P = 0.001; excretion, P = 0.032). CONCLUSION: The main protective effect of NAC becomes apparent 5 h after hepatic ischaemic injury.
Περιγραφή
Λέξεις-κλειδιά
Acetylcysteine/*administration & dosage, Animals, Free Radical Scavengers/*administration & dosage, Indocyanine Green/pharmacokinetics, Ischemic Preconditioning/methods, Liver/*blood supply, Liver Circulation, Liver Function Tests, Microcirculation, Rabbits, Reperfusion Injury/*prevention & control
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/15376207
http://onlinelibrary.wiley.com/store/10.1002/bjs.4694/asset/4694_ftp.pdf?v=1&t=h0nql5sr&s=7b5a227c8c0fafb89ab6cb84103958347318b4b6
http://onlinelibrary.wiley.com/store/10.1002/bjs.4694/asset/4694_ftp.pdf?v=1&t=h0nql5sr&s=7b5a227c8c0fafb89ab6cb84103958347318b4b6
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής