Acute phase proteins and interleukins in steady state sickle cell disease
Φόρτωση...
Ημερομηνία
Συγγραφείς
Bourantas, K. L.
Dalekos, G. N.
Makis, A.
Chaidos, A.
Tsiara, S.
Mavridis, A.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Eur J Haematol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
To identify a possible acute phase response during the steady state of sickle cell disease, we estimated the serum alterations of acute phase proteins, beta2-microglobulin (beta2M), kappa and lambda light chains, interleukins (ILs) and tumor necrosis factor-alpha (TNFalpha) in 21 patients. Increased concentrations of C-reactive protein (CRP) were found in 5 patients, alpha-1-acid-glycoprotein (AGP) in 3, alpha-1-antitrypsin (AAT) in 8, ceruloplasmin (CER) in 2, alpha-2-macroglobulin (AMG) in 14 and decreased haptoglobin (HPT) and transferrin (TFR) in 11 and 9, respectively. Increased beta2M was found in 10 patients and kappa and lambda light chains in 11. IL-1beta, IL-2, IL-4, IL-10 and TNFalpha were not detected in any of the patients. However, significantly increased values of IL-6 and sIL-2r were found. This study has demonstrated increased serum levels of some of the acute phase proteins in patients during the steady state of sickle cell disease. This may be a result of a subclinical vaso-occlusion which in turn leads to a covert inflammatory response. Cytokines, and in particular IL-6, produced after this response, seem to be responsible for the high levels of acute phase proteins in the steady state of this disease.
Περιγραφή
Λέξεις-κλειδιά
Acute-Phase Proteins/*analysis/*metabolism, Adolescent, Adult, Anemia, Sickle Cell/*blood/*metabolism, Child, Female, Humans, Interleukins/*blood/*metabolism, Male, Tumor Necrosis Factor-alpha/metabolism, beta 2-Microglobulin/metabolism, beta-Thalassemia/blood
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/9688292
http://onlinelibrary.wiley.com/store/10.1111/j.1600-0609.1998.tb01060.x/asset/j.1600-0609.1998.tb01060.x.pdf?v=1&t=h0t6hbk5&s=672ff15f90f70e988b845c7317cda0f5bd1fb831
http://onlinelibrary.wiley.com/store/10.1111/j.1600-0609.1998.tb01060.x/asset/j.1600-0609.1998.tb01060.x.pdf?v=1&t=h0t6hbk5&s=672ff15f90f70e988b845c7317cda0f5bd1fb831
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής