Mitotic phosphorylation of histone H3 at threonine 3
| dc.contributor.author | Polioudaki, H. | en |
| dc.contributor.author | Markaki, Y. | en |
| dc.contributor.author | Kourmouli, N. | en |
| dc.contributor.author | Dialynas, G. | en |
| dc.contributor.author | Theodoropoulos, P. A. | en |
| dc.contributor.author | Singh, P. B. | en |
| dc.contributor.author | Georgatos, S. D. | en |
| dc.date.accessioned | 2015-11-24T19:04:17Z | |
| dc.date.available | 2015-11-24T19:04:17Z | |
| dc.identifier.issn | 0014-5793 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/20010 | |
| dc.rights | Default Licence | - |
| dc.subject | Amino Acid Sequence | en |
| dc.subject | Animals | en |
| dc.subject | Blotting, Western | en |
| dc.subject | Cell Fractionation | en |
| dc.subject | Cell Nucleus/chemistry | en |
| dc.subject | Erythrocyte Membrane/chemistry | en |
| dc.subject | Erythrocytes/cytology | en |
| dc.subject | Glutathione Transferase/metabolism | en |
| dc.subject | Heterochromatin/chemistry | en |
| dc.subject | Histones/chemistry/*metabolism | en |
| dc.subject | Mitosis | en |
| dc.subject | Nuclear Envelope/chemistry | en |
| dc.subject | Phosphorylation | en |
| dc.subject | Protein Processing, Post-Translational/immunology | en |
| dc.subject | Recombinant Fusion Proteins/chemistry/metabolism | en |
| dc.subject | Threonine/*metabolism | en |
| dc.subject | Turkeys/blood | en |
| dc.title | Mitotic phosphorylation of histone H3 at threonine 3 | en |
| heal.abstract | Nuclear envelope-peripheral heterochromatin fractions contain multiple histone kinase activities. In vitro assays and amino-terminal sequencing show that one of these activities co-isolates with heterochromatin protein 1 (HP1) and phosphorylates histone H3 at threonine 3. Antibodies recognizing this post-translational modification reveal that in vivo phosphorylation at threonine 3 commences at early prophase in the vicinity of the nuclear envelope, spreads to pericentromeric chromatin during prometaphase and is fully reversed by late anaphase. This spatio-temporal pattern is distinct from H3 phosphorylation at serine 10, which also occurs during cell division, suggesting segregation of differentially phosphorylated chromatin to different regions of mitotic chromosomes. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1016/S0014-5793(04)00060-2 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/14987995 | - |
| heal.identifier.secondary | http://www.sciencedirect.com/science/article/pii/S0014579304000602 | - |
| heal.journalName | FEBS Lett | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2004 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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