Relation between burden of disease and randomised evidence in sub-Saharan Africa: survey of research
| dc.contributor.author | Isaakidis, P. | en |
| dc.contributor.author | Swingler, G. H. | en |
| dc.contributor.author | Pienaar, E. | en |
| dc.contributor.author | Volmink, J. | en |
| dc.contributor.author | Ioannidis, J. P. | en |
| dc.date.accessioned | 2015-11-24T18:54:36Z | |
| dc.date.available | 2015-11-24T18:54:36Z | |
| dc.identifier.issn | 1756-1833 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/18705 | |
| dc.rights | Default Licence | - |
| dc.subject | Africa South of the Sahara | en |
| dc.subject | *Cost of Illness | en |
| dc.subject | *Developing Countries | en |
| dc.subject | Health Services Needs and Demand/*statistics & numerical data | en |
| dc.subject | *Health Status | en |
| dc.subject | Humans | en |
| dc.subject | Randomized Controlled Trials as Topic/*utilization | en |
| dc.title | Relation between burden of disease and randomised evidence in sub-Saharan Africa: survey of research | en |
| heal.abstract | OBJECTIVE: To evaluate whether the amount of randomised clinical research on various medical conditions is related to the burden of disease and health needs of the local populations in sub-Saharan Africa. DESIGN: Construction and analysis of comprehensive database of randomised controlled trials in sub-Saharan Africa based on Medline, the Cochrane Controlled Trials Register, and several African databases. SETTING: Sub-Saharan Africa. MAIN OUTCOME MEASURES: Number of trials and randomised subjects for each category of disease in the global burden of disease taxonomy; ratios of disability adjusted life years (DALYs) per amount of randomised evidence. RESULTS: 1179 eligible randomised controlled trials were identified. The number of trials published each year increased over time. Almost half of the trials (n=565) had been done in South Africa. There was relatively good correlation between the estimated burden of disease at year 2000 and the number of trials performed (r=0.53, P=0.024) and the number of participants randomised (r=0.68, P=0.002). However,some conditions-for example, injuries (over 20 000 DALYs per patient ever randomised)-were more neglected than others. CONCLUSION: Despite recent improvements, few clinical trials are done in sub-Saharan Africa. Clinical research in this part of the world should focus more evenly on the major contributors to burden of disease. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/11909786 | - |
| heal.journalName | BMJ | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2002 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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