Feasibility study and pharmacokinetics of low-dose paclitaxel in cancer patients with severe hepatic dysfunction

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dc.contributor.authorBriasoulis, E.en
dc.contributor.authorKaravasilis, V.en
dc.contributor.authorTzamakou, E.en
dc.contributor.authorPiperidou, C.en
dc.contributor.authorSoulti, K.en
dc.contributor.authorPavlidis, N.en
dc.date.accessioned2015-11-24T19:16:03Z
dc.date.available2015-11-24T19:16:03Z
dc.identifier.issn0959-4973-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21608
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectAntineoplastic Agents, Phytogenic/administration & dosage/pharmacokineticsen
dc.subjectDose-Response Relationship, Drugen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectLiver Function Testsen
dc.subjectLiver Neoplasms/*drug therapy/physiopathology/secondaryen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPaclitaxel/*administration & dosage/*pharmacokineticsen
dc.titleFeasibility study and pharmacokinetics of low-dose paclitaxel in cancer patients with severe hepatic dysfunctionen
heal.abstractThe aim of this study is to investigate the feasibility and determine the pharmacokinetics of low-dose paclitaxel in cancer patients with severe hepatic dysfunction. This was a prospective study. Patients with liver metastases who had either transaminase serum levels higher than 10 times the upper normal limit or bilirubin serum levels higher than 5 times the upper normal limit were eligible. All patients underwent pharmacokinetic evaluation during the first course of treatment. Pharmacokinetics in severe hepatic dysfunction patients were compared with data from a reference group of patients with normal hepatic function who participated in a phase I study. Nine severe hepatic dysfunction patients were treated with paclitaxel 70 mg/m administered as a 1-h infusion every 2 weeks. They received a median three treatment courses (range 1-9) without clinically relevant toxicity. The area under the concentration-time curve of paclitaxel was markedly higher in severe hepatic dysfunction patients when compared with the normal hepatic function control group treated with the same dose (98% increase, P<0.001). Area under the concentration-time curve and the time above 0.1 micromol/l (T>0.1) concentration threshold in the severe hepatic dysfunction patients who received paclitaxel 70 mg/m approximated pharmacokinetics of paclitaxel in patients with normal liver function who received 130 mg/m. Maximum plasma concentration (Cmax) did not differ between the two groups. In conclusion, paclitaxel 70 mg/m was safely delivered every 2 weeks in patients with severe hepatic dysfunction and resulted in adequate plasma concentrations. Paclitaxel at this dosage can be taken as an option for severe hepatic dysfunction patients who are expected to get clinical benefits from taxanes.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1097/01.cad.0000236301.12715.6b-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17075322-
heal.journalNameAnticancer Drugsen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2006-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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