Synthesis and characterization of new water stable antimony(III) complex with pyrimidine-2-thione and in vitro biological study
Φόρτωση...
Ημερομηνία
Συγγραφείς
Hadjikakou, S. K.
Antoniadis, C. D.
Hadjiliadis, N.
Kubicki, M.
Binolis, J.
Karkabounas, S.
Charalabopoulos, K.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Elsevier
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Inorganica Chimica Acta
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
A novel water stable, antimony(III) complex with the heterocyclic thioamide, 2-mercapto-pyrimidine (pmtH), of formula [Sb(pmt)(3)]center dot 0.5(CH3OH), has been synthesized and characterized by elemental analysis, H-1, C-13 NMR and FT-IR spectroscopic techniques. Crystal structure of the molecule has been determined by X-ray diffraction at ambient conditions. The compound [C12H9N6S3Sb center dot 0.5(CH3OH)] is monoclinic, space group P2(1)/c, a=7.0646(7), b=16.3767(14), e=14.7265(13) angstrom, beta=92.016(7)degrees, Z=4. In complex, three sulfur and three nitrogen atoms from thione ligands form a distorted pendagonal pyramidal geometry around antimony(III). The toxicity of the compound against tumor pleiomorphic cells, which has been isolated from a leiomyosarcoma tumor in the Wistar rat (chemical carcinogenesis using BaP) was studied in vitro. The results show that the compound did not destroy or prevent multiplication in vitro in leiomyosarcoma cells in low doses. The influence of the compound in the platelet aggregation, which correlates with the above tumor cells enhanced metastatic potential, has also been studied. The anti-metastatic capability study shows that the compound inhibited cancer cell induced aggregation up to the value of 10% in all mM concentrations tested. (c) 2004 Elsevier B.V. All rights reserved.
Περιγραφή
Λέξεις-κλειδιά
bioinorganic chemistry, antimony(iii) complexes, ligands-heterocyclic thioamides, crystal structures, anti-tumor activity, cell aggregation study, visceral leishmaniasis, crystal-structure, diphenylantimony(iii) derivatives, molecular-structures, chemotherapy, interferon, ligands, bismuth, tumor, gamma
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000230225600004
http://ac.els-cdn.com/S0020169304003305/1-s2.0-S0020169304003305-main.pdf?_tid=5a73b375a0b2822d402d4da992371095&acdnat=1333030142_0a61f36a888d1dcbaf26b2ca14c3da72
http://ac.els-cdn.com/S0020169304003305/1-s2.0-S0020169304003305-main.pdf?_tid=5a73b375a0b2822d402d4da992371095&acdnat=1333030142_0a61f36a888d1dcbaf26b2ca14c3da72
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας