The effects of orlistat on metabolic parameters and other cardiovascular risk factors
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Kiortsis, D. N.
Filippatos, T. D.
Elisaf, M. S.
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peer-reviewed
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Diabetes & Metabolism
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Description
Orlistat is an antiobesity drug with a well documented efficacy in weight reduction and weight maintenance. Weight reduction with orlistat has been associated with a favourable effect on obesity-related cardiovascular risk factors. Orlistat treatment is associated with a reduction in serum insulin levels. Moreover, orlistat reduces the incidence of type 2 diabetes in patients with impaired glucose tolerance and lowers the required dose of metformin, sulfonylureas and insulin in patients with type 2 diabetes. Furthermore, orlistat can reduce total and low density lipoprotein (LDL) cholesterol levels and improve postprandial triglyceridemia, as well as the low density lipoprotein cholesterol / high density lipoprotein cholesterol ratio (LDL/HDL ratio). Moreover, orlistat appears to have a favourable effect on some inflammatory markers, such as TNF-alpha and interleukin-6 and has a time-depended effect on some haemostatic factors.
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Keywords
orlistat, weight loss, cholesterol, metabolic parameters, insulin, diabetes, coronary-heart-disease, randomized controlled-trial, placebo-controlled trial, obese-patients, weight-loss, lipase inhibitor, serum-lipids, double-blind, body-weight, postprandial lipemia
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<Go to ISI>://000227426300002
http://ac.els-cdn.com/S1262363607701611/1-s2.0-S1262363607701611-main.pdf?_tid=7941c0c88034fcd656dd9979e1d8130c&acdnat=1332756673_3043d3864000e468732cf0601204b908
http://ac.els-cdn.com/S1262363607701611/1-s2.0-S1262363607701611-main.pdf?_tid=7941c0c88034fcd656dd9979e1d8130c&acdnat=1332756673_3043d3864000e468732cf0601204b908
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en
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Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής