Installation and testing of an optimized epithermal neutron beam at the Brookhaven Medical Research Reactor (BMRR)

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dc.contributor.authorFairchild, R. G.en
dc.contributor.authorKalef-Ezra, J.en
dc.contributor.authorSaraf, S. K.en
dc.contributor.authorFiarman, S.en
dc.contributor.authorRamsey, E.en
dc.contributor.authorWielopolski, L.en
dc.contributor.authorLaster, B. H.en
dc.contributor.authorWheeler, F. J.en
dc.date.accessioned2015-11-24T19:09:42Z
dc.date.available2015-11-24T19:09:42Z
dc.identifier.issn0090-5542-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20735
dc.rightsDefault Licence-
dc.subjectBoron Compounds/therapeutic useen
dc.subjectBrain Neoplasms/radiotherapyen
dc.subjectFacility Design and Constructionen
dc.subjectHumansen
dc.subjectModels, Structuralen
dc.subjectNeutrons/*therapeutic useen
dc.subjectNuclear Reactors/*instrumentationen
dc.subjectRadiation-Sensitizing Agentsen
dc.subjectRadiotherapy Dosageen
dc.titleInstallation and testing of an optimized epithermal neutron beam at the Brookhaven Medical Research Reactor (BMRR)en
heal.abstractNCT is a binary system, in which 10B is physiologically targeted to tumor and then allowed to interact with thermal neutrons generated in the treatment volume by an externally applied neutron beam. Consequently, an unusually large number of parameters are obtained, which bear on the resultant Therapeutic Gain (TG). However, a perusal of these data, as illustrated in Figure 7, indicates that the TG would increase significantly beyond values projected in this paper if the absolute amount of 10B could be increased above 30 ppm. For example, increasing 10B concentration in tumor to 45 ppm would increase TG by approximately 33% (with a T/N of 5). A similar increase in TG would follow an increase in T/N from 5 to 10. Those associated with the development of boron compounds for NCT feel that such developments are within reach.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/2268239-
heal.journalNameBasic Life Scien
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1990-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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