A detailed behavioral analysis of the acute motor effects of caffeine in the rat: involvement of adenosine A1 and A2A receptors

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dc.contributor.authorAntoniou, K.en
dc.contributor.authorPapadopoulou-Daifoti, Z.en
dc.contributor.authorHyphantis, T.en
dc.contributor.authorPapathanasiou, G.en
dc.contributor.authorBekris, E.en
dc.contributor.authorMarselos, M.en
dc.contributor.authorPanlilio, L.en
dc.contributor.authorMuller, C. E.en
dc.contributor.authorGoldberg, S. R.en
dc.contributor.authorFerre, S.en
dc.date.accessioned2015-11-24T19:40:28Z
dc.date.available2015-11-24T19:40:28Z
dc.identifier.issn0033-3158-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24359
dc.rightsDefault Licence-
dc.subjectAdenosine/analogs & derivatives/pharmacologyen
dc.subjectAdenosine A1 Receptor Agonistsen
dc.subjectAdenosine A1 Receptor Antagonistsen
dc.subjectAdenosine A2 Receptor Agonistsen
dc.subjectAdenosine A2 Receptor Antagonistsen
dc.subjectAnalysis of Varianceen
dc.subjectAnimalsen
dc.subjectBehavior, Animal/*drug effectsen
dc.subjectCaffeine/*pharmacologyen
dc.subjectCentral Nervous System Stimulants/*pharmacologyen
dc.subjectDose-Response Relationship, Drugen
dc.subjectDrug Interactionsen
dc.subjectMaleen
dc.subjectMotor Activity/*drug effectsen
dc.subjectRatsen
dc.subjectRats, Sprague-Dawleyen
dc.subjectReceptor, Adenosine A1/*physiologyen
dc.subjectReceptors, Adenosine A2/*physiologyen
dc.subjectXanthines/pharmacologyen
dc.titleA detailed behavioral analysis of the acute motor effects of caffeine in the rat: involvement of adenosine A1 and A2A receptorsen
heal.abstractRATIONALE: There is no consensus on the contribution of adenosine A(1) and A(2A) receptor blockade to motor-activating effects of caffeine. OBJECTIVE: Our aim was to use a detailed and continuous observational method to compare the motor effects induced by caffeine with those induced by selective A(1) and A(2A) receptor antagonists. METHODS: The behavioral repertoire induced by systemic administration of caffeine (3, 10, and 30 mg/kg), A(1) receptor antagonist 8-cyclopentyl-1,3-dimethylxanthine (CPT; 1.2, 4.8 and 7.2 mg/kg), and A(2A) receptor antagonist 3-(3-hydroxypropyl)-8-(m-methoxystyryl)-7-methyl-1-propargylxanthine phosphate disodium salt (MSX-3; 1, 3, and 10 mg/kg) was analyzed. The effects of pretreatment with the selective A(1) receptor agonist N (6)-cyclopentyladenosine (CPA; 0.1 mg/g) and the selective A(2A) receptor agonist 2-p-(2-carboxyethyl)phenethylamino-5'-N-ethylcarboxyamidoadenosine (CGS 21680; 0.2 mg/kg) on the pattern of motor activation induced by caffeine, CPT, or MSX-3 were also examined. RESULTS: The pattern of behavioral activation induced by caffeine was better mimicked by CPT than by MSX-3. Coadministration of CPT and MSX-3 gave different results depending on the dose and the type of behavioral response. CPA was more effective at decreasing the activating effects of caffeine and CPT than those of CGS 21680. On the other hand, CGS 21680 was more effective at decreasing the activating effects of MSX-3 than those of caffeine or CPT. Factor analysis revealed a complex three-dimensional behavioral profile for caffeine that was similar to the profile for CPT and was different from the profile for MSX-3. CONCLUSIONS: The results indicate a predominant role for A(1) receptors in the motor-activating effects of acutely administered caffeine.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1007/s00213-005-0173-6-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16205915-
heal.identifier.secondaryhttp://www.springerlink.com/content/y33n3832m118631n/fulltext.pdf-
heal.journalNamePsychopharmacology (Berl)en
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2005-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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