Discordant expression of immunoglobulin and its associated molecule mb-1/CD79a is frequently found in mediastinal large B cell lymphomas

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dc.contributor.authorKanavaros, P.en
dc.contributor.authorGaulard, P.en
dc.contributor.authorCharlotte, F.en
dc.contributor.authorMartin, N.en
dc.contributor.authorDucos, C.en
dc.contributor.authorLebezu, M.en
dc.contributor.authorMason, D. Y.en
dc.date.accessioned2015-11-24T19:24:14Z
dc.date.available2015-11-24T19:24:14Z
dc.identifier.issn0002-9440-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22442
dc.rightsDefault Licence-
dc.subject*Antigens, CDen
dc.subjectAntigens, CD79en
dc.subjectHumansen
dc.subjectImmunoglobulins/*metabolismen
dc.subjectImmunophenotypingen
dc.subjectLymphoid Tissue/metabolismen
dc.subjectLymphoma, B-Cell/*metabolismen
dc.subjectLymphoma, Large B-Cell, Diffuse/*metabolismen
dc.subjectLymphoma, T-Cell/metabolismen
dc.subjectMediastinal Neoplasms/*metabolismen
dc.subjectMembrane Glycoproteins/*metabolismen
dc.subjectReceptors, Antigen, B-Cell/*metabolismen
dc.titleDiscordant expression of immunoglobulin and its associated molecule mb-1/CD79a is frequently found in mediastinal large B cell lymphomasen
heal.abstractMediastinal large B cell lymphomas are uncommon neoplasms that are thought to originate from thymic B cells. An unusual feature of these neoplasms is that they often lack surface immunoglobulin (Ig), a molecule ubiquitously expressed by most mature B cells. In the present study we have analyzed 12 cases of mediastinal large B cell lymphoma for the expression of the mb-1/CD79a polypeptide. This is a component, together with B29/CD79b, of a heterodimer that is associated with surface Ig on normal B cells. Our aim was to see whether loss of Ig in this type of lymphoma is associated with loss of the accompanying CD79a molecule. We have also evaluated 128 B cell lymphomas of other categories to see whether any of them show discordance between mb-1 and Ig expression and analyzed 30 T cell lymphomas as Ig-negative controls. We found that 5 of the 7 mediastinal large B cell lymphomas with interpretable staining results for both mb-1 and Ig, lack Ig but expressed CD79a (mb-1). This phenotype was very rare in other categories of B cell lymphoma, being found among 110 cases in only 5 cases that were all follicular lymphoma. The remaining 105 B cell lymphomas displayed mb-1+/Ig+ phenotype. All 30 T cell lymphomas were mb-1 negative. We conclude that discordant mb-1/Ig expression occurs commonly in mediastinal large B cell lymphomas. In addition, the finding that 11 of 12 of these neoplasms express a phenotype (CD10-, CD19+, CD20+, CD21-, CD22+, CD23-/+) that is very similar to that described for thymic medullary B cells reinforces the idea that most mediastinal large B cell lymphomas are of thymic B cell origin. The correlation between mb-1 and Ig staining patterns in B cell lymphomas of other categories reveals that in the majority (90%), expression of the antigen receptor complex parallels that of mature B cells. These data therefore confirm that the expression of the mb-1 protein provides independent strong evidence for the B lineage of lymphomas and may be used for their routine phenotypic characterization.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/7887454-
heal.journalNameAm J Patholen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1995-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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