HP1: facts, open questions, and speculation
| dc.contributor.author | Singh, P. B. | en |
| dc.contributor.author | Georgatos, S. D. | en |
| dc.date.accessioned | 2015-11-24T19:13:04Z | |
| dc.date.available | 2015-11-24T19:13:04Z | |
| dc.identifier.issn | 1047-8477 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/21149 | |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Chromosomal Proteins, Non-Histone/*chemistry | en |
| dc.subject | Circular Dichroism | en |
| dc.subject | Dimerization | en |
| dc.subject | Drosophila Proteins/*chemistry | en |
| dc.subject | Drosophila melanogaster | en |
| dc.subject | Heterochromatin/chemistry | en |
| dc.subject | Histones/chemistry | en |
| dc.subject | Models, Molecular | en |
| dc.subject | Nuclear Envelope/metabolism | en |
| dc.subject | Peptides/chemistry | en |
| dc.title | HP1: facts, open questions, and speculation | en |
| heal.abstract | The demonstration, over a decade ago, that HP1 is a highly conserved constituent of heterochromatin was accompanied by the explicit view that this protein plays a pivotal role in epigenetic regulation (P.B. Singh, J.R. Miller, J. Pearce, R. Kothary, R.D. Burton, R. Paro, T.C. James, and S.J. Gaunt, 1991, Nucleic Acids Res. 19, 789-794). Recent studies have confirmed this view, unveiling specific interactions of HP1 with a variety of histone and nonhistone proteins. We discuss here some of these observations, concentrating on structure-function relationships and intracellular dynamics. Integrating the available information, we also present a hypothetical model describing how HP1, acting as a bifunctional cross-linker, could organize peripheral heterochromatin and contribute in the compartmentalization of the cell nucleus. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/12490149 | - |
| heal.identifier.secondary | http://www.sciencedirect.com/science/article/pii/S1047847702005361 | - |
| heal.journalName | J Struct Biol | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2002 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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