Association between maternal and infant class I and II HLA alleles and of their concordance with the risk of perinatal HIV type 1 transmission

Απλή σελίδα τεκμηρίου
dc.contributor.authorPolycarpou, A.en
dc.contributor.authorNtais, C.en
dc.contributor.authorKorber, B. T.en
dc.contributor.authorElrich, H. A.en
dc.contributor.authorWinchester, R.en
dc.contributor.authorKrogstad, P.en
dc.contributor.authorWolinsky, S.en
dc.contributor.authorRostron, T.en
dc.contributor.authorRowland-Jones, S. L.en
dc.contributor.authorAmmann, A. J.en
dc.contributor.authorIoannidis, J. P.en
dc.date.accessioned2015-11-24T19:35:04Z
dc.date.available2015-11-24T19:35:04Z
dc.identifier.issn0889-2229-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23673
dc.rightsDefault Licence-
dc.subjectAcquired Immunodeficiency Syndrome/drug therapy/*transmission/virologyen
dc.subject*Allelesen
dc.subjectFemaleen
dc.subject*Genes, MHC Class Ien
dc.subject*Genes, MHC Class IIen
dc.subject*Hiv-1en
dc.subjectHumansen
dc.subjectInfant, Newbornen
dc.subject*Infectious Disease Transmission, Verticalen
dc.subjectPregnancyen
dc.subjectRisken
dc.subjectViral Loaden
dc.titleAssociation between maternal and infant class I and II HLA alleles and of their concordance with the risk of perinatal HIV type 1 transmissionen
heal.abstractWe aimed to investigate the influence of class I and class II HLA specificities and of the concordance between maternal and infant HLA on vertical HIV-1 transmission. HLA typing of samples from mothers and infants enrolled in the Ariel study, a perinatal HIV-1 transmission cohort including 203 mother-infant pairs, was performed by serological and molecular methods. HLA effects were evaluated alone and by multivariate modeling considering also other known predictors of perinatal HIV-1 transmission (maternal viral load, antiretroviral therapy, duration of rupture of membranes, and histological chorioamnionitis). Modest associations were seen with specific HLA markers (increased risk with infant B67 and B58 and maternal DR1; decreased risk with maternal B12), but these were not statistically significant after adjusting for multiple comparisons. Mother-infant concordance at any class I locus was a strong predictor of transmission (odds ratio [OR], 4.16; p = 0.028). Transmission was not associated with class II concordance. Class I HLA concordance retained its importance after adjusting for maternal viral load, antiretroviral therapy, duration of rupture of membranes or histological chorioamnionitis. In multivariate modeling, only class I concordance (OR, 3.59; p = 0.069) and chorioamnionitis (OR, 3.79; p = 0.030) were retained as independent predictors of transmission. HLA alleles, and in particular the class I concordance between maternal and neonatal HLA, may regulate the risk of perinatal HIV-1 transmission.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1089/08892220260139477-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/12167265-
heal.identifier.secondaryhttp://online.liebertpub.com/doi/pdfplus/10.1089/08892220260139477-
heal.journalNameAIDS Res Hum Retrovirusesen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2002-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ