Expression analysis of BCL2L12, a new member of apoptosis-related genes, in colon cancer

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dc.contributor.authorMathioudaki, K.en
dc.contributor.authorScorilas, A.en
dc.contributor.authorPapadokostopoulou, A.en
dc.contributor.authorXynopoulos, D.en
dc.contributor.authorArnogianaki, N.en
dc.contributor.authorAgnanti, N.en
dc.contributor.authorTalieri, M.en
dc.date.accessioned2015-11-24T19:16:53Z
dc.date.available2015-11-24T19:16:53Z
dc.identifier.issn1431-6730-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21718
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectApoptosis/*physiologyen
dc.subjectColonic Neoplasms/genetics/*metabolismen
dc.subjectDisease Progressionen
dc.subjectGene Expression Regulation, Neoplastic/genetics/*physiologyen
dc.subjectGenetic Markers/genetics/physiologyen
dc.subjectHumansen
dc.subjectMiddle Ageden
dc.subjectMuscle Proteins/*biosynthesis/geneticsen
dc.subjectProportional Hazards Modelsen
dc.subjectProtein Isoforms/biosynthesis/geneticsen
dc.subjectProto-Oncogene Proteins c-bcl-2/*biosynthesis/geneticsen
dc.subjectStatistics, Nonparametricen
dc.titleExpression analysis of BCL2L12, a new member of apoptosis-related genes, in colon canceren
heal.abstractApoptosis is an active process regulated by a variety of genes. Recently, the molecular cloning, physical mapping and expression analysis of a novel gene of the Bcl-2 family, BCL2L12, was reported. Expression analysis of the BCL2L12 gene in breast cancer confirmed an association of BCL2L12 with favorable prognosis of patients. In the present study, the expression of the BCL2L12 gene was analyzed in colon cancer by RT-PCR. Two transcripts, BCL2L12 and BCL2L12-A, were overexpressed in the cancer tissues as compared to their paired normal mucosa. An association was found between BCL2L12-A transcript expression and nodal status, as well as Dukes' stage. The BCL2L12-A transcript appears to be of importance for colon cancer since its expression is associated with disease progression.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1515/BC.2004.101-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15493871-
heal.identifier.secondaryhttp://www.degruyter.com/dg/viewarticle.fullcontentlink:pdfeventlink/contentUri?t:ac=j$002fbchm.2004.385.issue-9$002fbc.2004.101$002fbc.2004.101.xml-
heal.journalNameBiol Chemen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2004-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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