Combined treatment with fibrates and small doses of atorvastatin in patients with mixed hyperlipidemia

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dc.contributor.authorLiamis, G.en
dc.contributor.authorKakafika, A.en
dc.contributor.authorBairaktari, E.en
dc.contributor.authorMiltiadous, G.en
dc.contributor.authorTsimihodimos, V.en
dc.contributor.authorGoudevenos, J.en
dc.contributor.authorAchimastos, A.en
dc.contributor.authorElisaf, M. S.en
dc.date.accessioned2015-11-24T19:29:19Z
dc.date.available2015-11-24T19:29:19Z
dc.identifier.issn0300-7995-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22964
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAnticholesteremic Agents/therapeutic useen
dc.subjectClofibric Acid/administration & dosage/*analogs & derivatives/*therapeutic useen
dc.subjectDrug Administration Scheduleen
dc.subjectDrug Therapy, Combinationen
dc.subjectFemaleen
dc.subjectFenofibrate/administration & dosage/*therapeutic useen
dc.subjectFibric Acidsen
dc.subjectHeptanoic Acids/administration & dosage/*therapeutic useen
dc.subjectHumansen
dc.subjectHydroxymethylglutaryl-CoA Reductase Inhibitors/administration &en
dc.subjectdosage/*therapeutic useen
dc.subjectHyperlipoproteinemia Type V/blood/*drug therapy/enzymologyen
dc.subjectHypolipidemic Agents/administration & dosage/*therapeutic useen
dc.subjectLipids/*blooden
dc.subjectLiver/enzymologyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPyrroles/administration & dosage/*therapeutic useen
dc.subjectTreatment Outcomeen
dc.titleCombined treatment with fibrates and small doses of atorvastatin in patients with mixed hyperlipidemiaen
heal.abstractCombined statin and fibrate therapy is often imperative for the improvement of the serum lipid profile in patients with mixed hyperlipidemia. However, the potential risk of myopathy has limited the widespread use of such therapy. Preferably this treatment should involve low optimally tolerable doses of hypolipidemic drugs. Thus, we undertook a study to determine the safety and efficacy of combination therapy with fibrates and small doses of atorvastatin. Twenty-two patients with mixed hyperlipidemia were started on a fibrate regimen (micronised fenofibrate 200mg/day or ciprofibrate 100 mg/day). Because after 12 weeks of therapy the fibrate failed to normalise the serum lipid profile, small doses of atorvastatin (5 mg/day) were added for a further 12 weeks. The administration of the fibrates resulted in a significant decrease in total and LDL-cholesterol levels, as well as in triglycerides, and an increase in HDL-cholesterol levels. The addition of atorvastatin (5 mg/day) resulted in a further decrease in total and LDL-cholesterol levels. Consequently, the hypolipidemic therapy target was achieved in most of the patents. Combination therapy was well tolerated and no significant increases in serum liver and muscle enzymes were noticed. We conclude that the careful administration of small doses of atorvastatin in patients with mixed dyslipidemia receiving fibrates is associated with a significant amelioration of lipid abnormalities.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/12094821-
heal.identifier.secondaryhttp://informahealthcare.com/doi/abs/10.1185/030079902125000372-
heal.journalNameCurrent Medical Research and Opinionen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2002-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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