Is the combination of 5-fluorouracil and folinic acid effective in advanced gastric carcinoma? Results of a pilot study and review of the literature
| dc.contributor.author | Pavlidis, N. | en |
| dc.contributor.author | Nicolaides, C. | en |
| dc.contributor.author | Klouvas, G. | en |
| dc.contributor.author | Briassoulis, E. | en |
| dc.date.accessioned | 2015-11-24T19:08:50Z | |
| dc.date.available | 2015-11-24T19:08:50Z | |
| dc.identifier.issn | 1120-009X | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/20601 | |
| dc.rights | Default Licence | - |
| dc.subject | Adenocarcinoma/*drug therapy/mortality | en |
| dc.subject | Adult | en |
| dc.subject | Aged | en |
| dc.subject | Antineoplastic Combined Chemotherapy Protocols/adverse effects/*therapeutic use | en |
| dc.subject | Female | en |
| dc.subject | Fluorouracil/administration & dosage/adverse effects | en |
| dc.subject | Humans | en |
| dc.subject | Leucovorin/administration & dosage/adverse effects | en |
| dc.subject | Male | en |
| dc.subject | Middle Aged | en |
| dc.subject | Pilot Projects | en |
| dc.subject | Stomach Neoplasms/*drug therapy/mortality | en |
| dc.title | Is the combination of 5-fluorouracil and folinic acid effective in advanced gastric carcinoma? Results of a pilot study and review of the literature | en |
| heal.abstract | The main purpose of this trial was to investigate the activity of a less toxic regimen in patients with advanced gastric carcinoma regarding response rate and survival. We report on a pilot study of 20 patients treated with the combination of 5-fluorouracil and folinic acid. 5-fluorouracil was administered at a daily dose of 450 mg/m2 followed by folinic acid 200 mg/m2 for four consecutive days every four weeks. The overall response rate was 15% with one complete and two partial responders. The median duration of response was 11, 10 and 10 months respectively. The median survival of all patients was 9 months. Toxicity was mild and consisted primarily of diarrhea. Stomatitis and myelosuppression occurred rarely. In conclusion, the combination of 5-fluorouracil and folinic acid has moderate activity in gastric cancer, while median survival appears similar to the other more intensive regimens. The combination is very well tolerated with minimal toxicity. A detailed review of the literature regarding the effectiveness of the above regimens on response rate, overall survival and toxicity is also presented. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/7699431 | - |
| heal.journalName | J Chemother | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1994 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
Αρχεία
Φάκελος/Πακέτο αδειών
1 - 1 of 1
Φόρτωση...
- Ονομα:
- license.txt
- Μέγεθος:
- 1.74 KB
- Μορφότυπο:
- Item-specific license agreed upon to submission
- Περιγραφή: