Serum and tissue selenium levels in gastric cancer patients and correlation with CEA

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dc.contributor.authorCharalabopoulos, K.en
dc.contributor.authorKotsalos, A.en
dc.contributor.authorBatistatou, A.en
dc.contributor.authorCharalabopoulos, A.en
dc.contributor.authorPeschos, D.en
dc.contributor.authorVezyraki, P.en
dc.contributor.authorKalfakakou, V.en
dc.contributor.authorMetsios, A.en
dc.contributor.authorCharalampopoulos, A.en
dc.contributor.authorMacheras, A.en
dc.contributor.authorAgnantis, N.en
dc.contributor.authorEvangelou, A.en
dc.date.accessioned2015-11-24T18:52:12Z
dc.date.available2015-11-24T18:52:12Z
dc.identifier.issn1791-7530-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18371
dc.rightsDefault Licence-
dc.subjectAdenocarcinoma/*metabolism/secondaryen
dc.subjectCarcinoembryonic Antigen/*blooden
dc.subjectCase-Control Studiesen
dc.subjectFemaleen
dc.subjectFluorometryen
dc.subjectHumansen
dc.subjectImmunoenzyme Techniquesen
dc.subjectImmunoradiometric Assayen
dc.subjectIntestinal Neoplasms/*metabolism/pathologyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectNeoplasm Stagingen
dc.subjectPrognosisen
dc.subjectSelenium/*metabolismen
dc.subjectStomach Neoplasms/*metabolism/pathologyen
dc.subjectTumor Markers, Biological/*blooden
dc.titleSerum and tissue selenium levels in gastric cancer patients and correlation with CEAen
heal.abstractBACKGROUND: An inverse relationship between selenium (Se) intake and cancer mortality is evident in humans. MATERIALS AND METHODS: In eighty patients who had been operated on for primary gastric cancer, serum Se and carcinoembryonic antigen (CEA) levels were measured preoperatively using a fluorometric and immunoradiometric assay (IRMA), respectively. RESULTS: The serum Se levels were 43+/-6.3 microg l(-1) in the patient group and 68.7+/-4.5 microg l(-1) in healthy individuals (p<0.001). The serum CEA was 12+/-1.9 U ml(-1) in the gastric cancer patients and 2.1 U ml(-1) in the control group (p<0.001). The Se tissue concentrations were 2,640+/-220 mg g(-1) in excised neoplastic tissue and 685+/-115 mg g(-1) in non-neoplastic tissue (p<0.001). An inverse correlation between Se and CEA serum levels was found (r=-0.782). There was no correlation between serum/tissue Se concentration and disease stage/histological type or gender in the patient group.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/19661375-
heal.journalNameAnticancer Resen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2009-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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