Treatment of experimental allergic encephalomyelitis (EAE) by a rationally designed cyclic analogue of myelin basic protein (MBP) epitope 72-85

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dc.contributor.authorTselios, T.en
dc.contributor.authorDaliani, I.en
dc.contributor.authorDeraos, S.en
dc.contributor.authorThymianou, S.en
dc.contributor.authorMatsoukas, E.en
dc.contributor.authorTroganis, A.en
dc.contributor.authorGerothanassis, I.en
dc.contributor.authorMouzaki, A.en
dc.contributor.authorMavromoustakos, T.en
dc.contributor.authorProbert, L.en
dc.contributor.authorMatsoukas, J.en
dc.date.accessioned2015-11-24T16:51:46Z
dc.date.available2015-11-24T16:51:46Z
dc.identifier.issn0960-894X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9783
dc.rightsDefault Licence-
dc.subjectpeptide analogsen
dc.subjectangiotensin-iien
dc.subjectlymphocyte-ten
dc.subjectconformationen
dc.subjectbackboneen
dc.subjectligandsen
dc.subjectclonesen
dc.subjectdomainen
dc.subjectraten
dc.titleTreatment of experimental allergic encephalomyelitis (EAE) by a rationally designed cyclic analogue of myelin basic protein (MBP) epitope 72-85en
heal.abstractIn this report the rational design, synthesis and pharmacological properties of an amide-linked cyclic antagonist analogue of the guinea pig myelin basic protein epitope MBP72-85 are described. Design of the potent cyclic analogue was based on 2D NOESY nuclear magnetic resonance and molecular dynamics studies carried out in the linear antagonist Alas(81)MBP(72-85). The cyclic antagonist completely prevented the induction of experimental allergic/autoimmune encephalomyelitis when coinjected with linear and cyclic agonist analogues MBP72-85 and cyclo(2-9)MBP72-85. (C) 2000 Elsevier Science Ltd. All rights reserved.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondary<Go to ISI>://000165849700006-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0960894X00005564/1-s2.0-S0960894X00005564-main.pdf?_tid=a0e8d7eb08709cf1e847f2a848c7e6ad&acdnat=1333029910_2cffba4bb40d634dd8e10faab867f92f-
heal.journalNameBioorg Med Chem Letten
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2000-
heal.publisherElsevieren
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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