Early prenatal diagnosis by celocentesis
Φόρτωση...
Ημερομηνία
Συγγραφείς
Makrydimas, G.
Georgiou, I.
Bouba, I.
Lolis, D.
Nicolaides, K. H.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Ultrasound Obstet Gynecol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
BACKGROUND: Celocentesis is the ultrasound-guided aspiration of fluid from the extra-amniotic cavity at 7-8 weeks of gestation. This paper reports on the clinical application of celocentesis for early prenatal diagnosis. METHODS: Celocentesis was successfully performed in nine pregnancies and 1-2 mL of fluid were obtained after one needle insertion. The indications were prenatal diagnosis of beta-thalassemia or sickle cell disease (n = 6), Marfan syndrome (n = 1) and paternity testing (n = 2). Molecular biological techniques were used to analyze the celomic fluid and this was successfully carried out in all cases. RESULTS: In two cases pregnancy termination was performed at the request of the mother because in one case the fetus was found to have sickle cell anemia and in the second case paternity testing demonstrated that the father was not the woman's husband. In both cases the results were confirmed using the placental samples collected after pregnancy termination. In six of the seven pregnancies with desirable results, amniocentesis was performed at 16 weeks and the results were concordant with those obtained from celocentesis. All pregnancies were uneventful and resulted in the delivery of healthy and appropriately grown babies. CONCLUSION: Celocentesis may be a viable alternative to the currently used tests of chorionic villus sampling and amniocentesis.
Περιγραφή
Λέξεις-κλειδιά
Anemia, Sickle Cell/*diagnosis/embryology, Biopsy, Needle/methods, Body Fluids, Female, Humans, Paracentesis/*methods, Pregnancy, Pregnancy Outcome, Pregnancy Trimester, First, Prenatal Diagnosis/*methods, Sequence Analysis, DNA, Specimen Handling/methods, Ultrasonography, Interventional, Ultrasonography, Prenatal, Uterus/ultrasonography, beta-Thalassemia/*diagnosis/embryology
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/15133800
http://onlinelibrary.wiley.com/store/10.1002/uog.1046/asset/1046_ftp.pdf?v=1&t=h0l49jae&s=4973cdf4b819088169fd5d66e437d86384c431a3
http://onlinelibrary.wiley.com/store/10.1002/uog.1046/asset/1046_ftp.pdf?v=1&t=h0l49jae&s=4973cdf4b819088169fd5d66e437d86384c431a3
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής