Platinum(II) and palladium(II) complexes with 2-acetylpyridine thiosemicarbazone: cytogenetic and antineoplastic effects

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dc.contributor.authorIakovidou, Z.en
dc.contributor.authorPapageorgiou, A.en
dc.contributor.authorDemertzis, M. A.en
dc.contributor.authorMioglou, E.en
dc.contributor.authorMourelatos, D.en
dc.contributor.authorKotsis, A.en
dc.contributor.authorYadav, P. N.en
dc.contributor.authorKovala-Demertzi, D.en
dc.date.accessioned2015-11-24T16:45:04Z
dc.date.available2015-11-24T16:45:04Z
dc.identifier.issn0959-4973-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/8880
dc.rightsDefault Licence-
dc.subject2-acetylpyridine thiosemicarbazoneen
dc.subjectantileukemic activityen
dc.subjectcell kineticsen
dc.subjectpalladium(ii)en
dc.subjectplatinum(ii)en
dc.subjectsister chromatid exchangesen
dc.subjectchromatid exchange assayen
dc.subjectspectral propertiesen
dc.subjectcellsen
dc.subjectcyclophosphamideen
dc.subjectpredictionen
dc.subjecttumorsen
dc.subjectinvivoen
dc.titlePlatinum(II) and palladium(II) complexes with 2-acetylpyridine thiosemicarbazone: cytogenetic and antineoplastic effectsen
heal.abstractThe effect of three novel complexes of Pt(II) and three complexes of Pd(II) with 2-acetylpyridine thiosemicarbazone (HAcTsc) on sister chromatid exchange (SCE) rates and human lymphocyte proliferation kinetics on a molar basis was studied. Also, the effect of Pt(II) and Pd(II) complexes against leukemia P388 was investigated. Among these compounds, the most effective in inducing antitumor and cytogenetic effects were the complexes [Pt(AcTsc)(2)].H2O and [Pd(AcTsc)(2)] while the rest, i.e. (HAcTsc), [Pt(AcTsc)CI], [Pt(HAcTsc)(2)]Cl-2. 2H(2)O, [Pd(AcTsc)Cl] and [Pd(HAcTsc)(2)]Cl-2, displayed marginal cytogenetic and antitumor effects. [(C) 2001 Lippincott Williams & Wilkins.].en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondary<Go to ISI>://000166756100009-
heal.journalNameAnticancer Drugsen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2001-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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