Expression of the cell-cycle regulatory proteins (cyclins D1 and E) in endometrial carcinomas: correlations with hormone receptor status, proliferating indices, tumor suppressor gene products (p53, pRb), and clinicopathological parameters

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dc.contributor.authorMitselou, A.en
dc.contributor.authorIoachim, E.en
dc.contributor.authorZagorianakou, N.en
dc.contributor.authorKitsiou, E.en
dc.contributor.authorVougiouklakis, T.en
dc.contributor.authorAgnantis, N. J.en
dc.date.accessioned2015-11-24T19:16:33Z
dc.date.available2015-11-24T19:16:33Z
dc.identifier.issn0392-2936-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21679
dc.rightsDefault Licence-
dc.subjectCase-Control Studiesen
dc.subjectCyclin D1/*metabolismen
dc.subjectCyclin E/*metabolismen
dc.subjectEndometrial Neoplasms/*metabolism/pathologyen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectKi-67 Antigen/metabolismen
dc.subjectNeoplasm Stagingen
dc.subjectProliferating Cell Nuclear Antigen/metabolismen
dc.subjectTumor Suppressor Protein p53/metabolismen
dc.titleExpression of the cell-cycle regulatory proteins (cyclins D1 and E) in endometrial carcinomas: correlations with hormone receptor status, proliferating indices, tumor suppressor gene products (p53, pRb), and clinicopathological parametersen
heal.abstractPURPOSE OF INVESTIGATION: This study aimed to investigate the immunohistochemical expression of cyclins D1 and E in normal, hyperplastic and neoplastic endometrium, and their correlation with proliferative activity and clinicopathological features. METHODS: We carried out immunohistochemical techniques on archived material of formalin-fixed paraffin-embedded tissues using the antibodies against the cyclins D1 and E, PR-ER, p53, Ki67 (MIB1) and pRb with the streptavidin-biotin-peroxidase method in a total of 20 cases of normal endometrium, 32 cases of hyperplastic endometrium and 66 cases of endometrial carcinomas. RESULTS: Cyclin D1 and E immunoreactivity was observed in the nuclei of tumour cells in 18.2% and 39.1%, respectively, of the cases of endometrial carcinomas. Cyclin D1 labelling index was not significantly correlated with any of the clinicopathologic parameters examined. However, there was a significant correlation between the cyclin E labelling index and histological grade of carcinoma (p = 0.00096), which increased significantly with histological grades of malignancy. We also detected a significant correlation between cyclin E and PCNA (p < 0.0001) as well as with the tumor suppressor genes p53 and pRb (p = 0.052 and 0.0002, respectively) in endometrioid endometrial carcinoma. CONCLUSION: Our results indicate that cyclin E overexpression may be involved in the development and/or proliferation and differentiation of human endometrioid endometrial carcinoma. Immunoexpression of cyclin D1 does not appear to be associated with cell-cycle progression in the benign or malignant endometrium.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15597850-
heal.journalNameEur J Gynaecol Oncolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2004-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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