Targeting Antigens to Dendritic Cell Receptors for Vaccine Development
| dc.contributor.author | Apostolopoulos, V. | en |
| dc.contributor.author | Thalhammer, T. | en |
| dc.contributor.author | Tzakos, A. G. | en |
| dc.contributor.author | Stojanovska, L. | en |
| dc.date.accessioned | 2015-11-24T16:49:57Z | |
| dc.date.available | 2015-11-24T16:49:57Z | |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/9550 | |
| dc.rights | Default Licence | - |
| dc.title | Targeting Antigens to Dendritic Cell Receptors for Vaccine Development | en |
| heal.abstract | Dendritic cells (DCs) are highly specialized antigen presenting cells of the immune system which play a key role in regulating immune responses. Depending on the method of antigen delivery, DCs stimulate immune responses or induce tolerance. As a consequence of the dual function of DCs, DCs are studied in the context of immunotherapy for both cancer and autoimmune diseases. In vaccine development, a major aim is to induce strong, specific T-cell responses. This is achieved by targeting antigen to cell surface molecules on DCs that efficiently channel the antigen into endocytic compartments for loading onto MHC molecules and stimulation of T-cell responses. The most attractive cell surface receptors, expressed on DCs used as targets for antigen delivery for cancer and other diseases, are discussed. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | http://dx.doi.org/10.1155/2013/869718 | - |
| heal.identifier.secondary | http://www.hindawi.com/journals/jdd/2013/869718/ | - |
| heal.journalName | J Drug Deliv | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2013 | - |
| heal.publisher | Hindawi Publishing Corporation | en |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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