Bone loss in young women with karyotypically normal spontaneous premature ovarian failure
| dc.contributor.author | Anasti, J. N. | en |
| dc.contributor.author | Kalantaridou, S. N. | en |
| dc.contributor.author | Kimzey, L. M. | en |
| dc.contributor.author | Defensor, R. A. | en |
| dc.contributor.author | Nelson, L. M. | en |
| dc.date.accessioned | 2015-11-24T19:32:33Z | |
| dc.date.available | 2015-11-24T19:32:33Z | |
| dc.identifier.issn | 0029-7844 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/23423 | |
| dc.rights | Default Licence | - |
| dc.subject | Absorptiometry, Photon | en |
| dc.subject | Adult | en |
| dc.subject | Body Mass Index | en |
| dc.subject | Bone Density/*physiology | en |
| dc.subject | Bone Resorption/*physiopathology/radionuclide imaging | en |
| dc.subject | Female | en |
| dc.subject | Femur Neck/*physiology/radionuclide imaging | en |
| dc.subject | Humans | en |
| dc.subject | Karyotyping | en |
| dc.subject | Primary Ovarian Insufficiency/*complications/physiopathology/radionuclide imaging | en |
| dc.subject | Prospective Studies | en |
| dc.subject | Spine/*physiology/radionuclide imaging | en |
| dc.title | Bone loss in young women with karyotypically normal spontaneous premature ovarian failure | en |
| heal.abstract | OBJECTIVE: To evaluate the effects of karotypically normal spontaneous premature ovarian failure on femoral neck bone mineral density. METHODS: Eighty-nine women with karyotypically normal spontaneous premature ovarian failure who desired fertility were evaluated at a tertiary care academic center and underwent hip and spinal bone density measurements by conventional dual-photon absorptiometry. Seventy-seven of the women (87%) had sought medical advice previously and had taken a variety of estrogen and progestin replacement regimens at least intermittently. The median (range) age was 32 (20-39) years, and the median (range) time since diagnosis was 1.5 (0.5-11) years. Findings were compared with a reference group of 218 regularly menstruating women of similar age. RESULTS: Sixty of the 89 women with premature ovarian failure (67%, 95% confidence interval 57, 77) had a femoral neck bone mineral density more than 1 standard deviation (SD) below the mean of the reference group (P < .001, chi2 with Yates correction). Even in women in whom the bone mineral density measurement was made within just 1.5 years of the diagnosis, nearly one-half (47%) had a femoral neck bone mineral density more than 1 SD below the mean of the reference group (P < .01). CONCLUSION: Two-thirds of young women with karyotypically normal spontaneous premature ovarian failure have a femoral neck bone mineral density more than 1 SD below the mean of a reference group. These young women need early education regarding strategies to maintain their bone mass and ongoing medical evaluation to maintain compliance with these strategies. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/9464713 | - |
| heal.journalName | Obstet Gynecol | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1998 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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