The N-myc oncogene in human neuroblastoma cells: down-regulation of an angiogenesis inhibitor identified as activin A
Φόρτωση...
Ημερομηνία
Συγγραφείς
Breit, S.
Ashman, K.
Wilting, J.
Rossler, J.
Hatzi, E.
Fotsis, T.
Schweigerer, L.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Cancer Res
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Angiogenesis, the formation of new blood vessels, is seen during embryonic development and tumor progression, but the mechanisms have remained unclear. Recent data indicate that developmental and tumor angiogenesis can be induced by cellular oncogenes, leading to the enhanced activity of molecules stimulating angiogenesis. However, activated oncogenes might also facilitate angiogenesis by down-regulating endogenous inhibitors of angiogenesis. We report here that enhanced expression of the N-myc oncogene in human neuroblastoma cells down-regulates an inhibitor of endothelial cell proliferation, identified by amino acid sequencing as being identical with activin A, a developmentally regulated protein. Down-regulation appears to involve interaction of the N-Myc protein with the activin A promoter. In addition, activin A inhibits both endothelial cell proliferation in vitro and angiogenesis in vivo, and it induces hemorrhage in vivo. We suggest that the N-myc-induced down-regulation of activin A could contribute to developmental and tumor angiogenesis.
Περιγραφή
Λέξεις-κλειδιά
Activins, Amino Acid Sequence, Angiogenesis Inhibitors/*genetics/isolation & purification/pharmacology, Animals, Cattle, Cell Division/drug effects, Chick Embryo, Down-Regulation/physiology, Endothelial Growth Factors/genetics/isolation & purification, Endothelium, Vascular/chemistry/drug effects/metabolism, Gene Expression Regulation, Neoplastic/physiology, Genes, myc/*genetics, Humans, Inhibins/*genetics/isolation & purification/pharmacology, Molecular Sequence Data, Neovascularization, Pathologic/*drug therapy/genetics, Neuroblastoma/blood supply/*genetics/metabolism, Recombinant Proteins/genetics/pharmacology, Sequence Homology, Amino Acid, Transcription, Genetic/physiology, Transfection, Tumor Cells, Cultured
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/10969812
http://cancerres.aacrjournals.org/content/60/16/4596.full.pdf
http://cancerres.aacrjournals.org/content/60/16/4596.full.pdf
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής