The N-myc oncogene in human neuroblastoma cells: down-regulation of an angiogenesis inhibitor identified as activin A

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dc.contributor.authorBreit, S.en
dc.contributor.authorAshman, K.en
dc.contributor.authorWilting, J.en
dc.contributor.authorRossler, J.en
dc.contributor.authorHatzi, E.en
dc.contributor.authorFotsis, T.en
dc.contributor.authorSchweigerer, L.en
dc.date.accessioned2015-11-24T19:36:23Z
dc.date.available2015-11-24T19:36:23Z
dc.identifier.issn0008-5472-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23865
dc.rightsDefault Licence-
dc.subjectActivinsen
dc.subjectAmino Acid Sequenceen
dc.subjectAngiogenesis Inhibitors/*genetics/isolation & purification/pharmacologyen
dc.subjectAnimalsen
dc.subjectCattleen
dc.subjectCell Division/drug effectsen
dc.subjectChick Embryoen
dc.subjectDown-Regulation/physiologyen
dc.subjectEndothelial Growth Factors/genetics/isolation & purificationen
dc.subjectEndothelium, Vascular/chemistry/drug effects/metabolismen
dc.subjectGene Expression Regulation, Neoplastic/physiologyen
dc.subjectGenes, myc/*geneticsen
dc.subjectHumansen
dc.subjectInhibins/*genetics/isolation & purification/pharmacologyen
dc.subjectMolecular Sequence Dataen
dc.subjectNeovascularization, Pathologic/*drug therapy/geneticsen
dc.subjectNeuroblastoma/blood supply/*genetics/metabolismen
dc.subjectRecombinant Proteins/genetics/pharmacologyen
dc.subjectSequence Homology, Amino Aciden
dc.subjectTranscription, Genetic/physiologyen
dc.subjectTransfectionen
dc.subjectTumor Cells, Cultureden
dc.titleThe N-myc oncogene in human neuroblastoma cells: down-regulation of an angiogenesis inhibitor identified as activin Aen
heal.abstractAngiogenesis, the formation of new blood vessels, is seen during embryonic development and tumor progression, but the mechanisms have remained unclear. Recent data indicate that developmental and tumor angiogenesis can be induced by cellular oncogenes, leading to the enhanced activity of molecules stimulating angiogenesis. However, activated oncogenes might also facilitate angiogenesis by down-regulating endogenous inhibitors of angiogenesis. We report here that enhanced expression of the N-myc oncogene in human neuroblastoma cells down-regulates an inhibitor of endothelial cell proliferation, identified by amino acid sequencing as being identical with activin A, a developmentally regulated protein. Down-regulation appears to involve interaction of the N-Myc protein with the activin A promoter. In addition, activin A inhibits both endothelial cell proliferation in vitro and angiogenesis in vivo, and it induces hemorrhage in vivo. We suggest that the N-myc-induced down-regulation of activin A could contribute to developmental and tumor angiogenesis.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/10969812-
heal.identifier.secondaryhttp://cancerres.aacrjournals.org/content/60/16/4596.full.pdf-
heal.journalNameCancer Resen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2000-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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